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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:loxoprofen
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Accession:CHEBI:76172 term browser browse the term
Definition:A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration.
Synonyms:exact_synonym: 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid
 related_synonym: (+-)-((2-oxocyclopentyl)methyl)hydratropic acid;   Formula=C15H18O3;   InChI=1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18);   InChIKey=YMBXTVYHTMGZDW-UHFFFAOYSA-N;   SMILES=CC(C(O)=O)c1ccc(CC2CCCC2=O)cc1;   loxoprofene;   loxoprofeno;   loxoprofenum
 xref: CAS:68767-14-6;   Drug_Central:1615;   HMDB:HMDB0041920;   KEGG:D08149;   LINCS:LSM-5054
 xref_mesh: MESH:C040656
 xref: Patent:EP1767218;   Patent:WO2008020270;   Reaxys:2860055;   Wikipedia:Loxoprofen
 cyclic_relationship: is_conjugate_acid_of CHEBI:76199


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loxoprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cldn1 claudin 1 increases expression ISO loxoprofen metabolite results in increased expression of CLDN1 protein; loxoprofen results in increased expression of CLDN1 mRNA; loxoprofen results in increased expression of CLDN1 protein CTD PMID:34506768 NCBI chr16:26,175,395...26,190,589
Ensembl chr16:26,175,392...26,190,591 		JBrowse link
G Cldn3 claudin 3 increases expression ISO loxoprofen metabolite results in increased expression of CLDN3 protein; loxoprofen results in increased expression of CLDN3 mRNA; loxoprofen results in increased expression of CLDN3 protein CTD PMID:34506768 NCBI chr 5:135,015,068...135,016,330
Ensembl chr 5:135,015,068...135,016,326 		JBrowse link
G Cldn5 claudin 5 increases expression ISO loxoprofen metabolite results in increased expression of CLDN5 protein; loxoprofen results in increased expression of CLDN5 mRNA; loxoprofen results in increased expression of CLDN5 protein CTD PMID:34506768 NCBI chr16:18,595,597...18,597,012
Ensembl chr16:18,595,597...18,597,012 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO loxoprofen metabolite results in decreased phosphorylation of MAPK1 protein; loxoprofen results in decreased phosphorylation of MAPK1 protein CTD PMID:34506768 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation ISO loxoprofen metabolite results in decreased phosphorylation of MAPK3 protein; loxoprofen results in decreased phosphorylation of MAPK3 protein CTD PMID:34506768 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mpo myeloperoxidase increases activity ISO loxoprofen results in increased activity of MPO protein CTD PMID:20586851 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Muc2 mucin 2 multiple interactions
decreases expression		 ISO lafutidine inhibits the reaction [loxoprofen results in decreased expression of MUC2] CTD PMID:20586851 NCBI chr 7:141,276,583...141,308,428
Ensembl chr 7:141,276,583...141,308,430 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression
multiple interactions		 ISO loxoprofen results in increased expression of NOS2
lafutidine inhibits the reaction [loxoprofen results in increased expression of NOS2]		 CTD PMID:20586851 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22205
    role 22190
      application 21776
        pro-agent 11504
          prodrug 11240
            loxoprofen 8
              (2S)-2-(4-\{[(1R,2S)-2-hydroxycyclopentyl]methyl\}phenyl)propanoic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22205
    subatomic particle 22197
      composite particle 22197
        hadron 22197
          baryon 22197
            nucleon 22169
              atomic nucleus 22197
                atom 22197
                  main group element atom 22131
                    p-block element atom 22131
                      carbon group element atom 21928
                        carbon atom 21854
                          organic molecular entity 21854
                            heteroorganic entity 21512
                              organochalcogen compound 21001
                                organooxygen compound 20845
                                  carbon oxoacid 19638
                                    carboxylic acid 19631
                                      monocarboxylic acid 19001
                                        fatty acid 17244
                                          saturated fatty acid 16973
                                            propionic acid 3844
                                              loxoprofen 8
                                                (2S)-2-(4-\{[(1R,2S)-2-hydroxycyclopentyl]methyl\}phenyl)propanoic acid 0
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