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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nicotinic acid-adenine dinucleotide phosphate
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Accession:CHEBI:76072 term browser browse the term
Definition:A nicotinic acid dinucleotide that is NADP(+) in which the carboxamide group on the pyridine ring is replaced by a carboxy group.
Synonyms:exact_synonym: 2'-O-phosphonoadenosine 5'-{3-[1-(3-carboxypyridinio)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate}
 related_synonym: Formula=C21H28N6O18P3;   InChI=1S/C21H27N6O18P3/c22-17-12-18(24-7-23-17)27(8-25-12)20-16(44-46(33,34)35)14(29)11(43-20)6-41-48(38,39)45-47(36,37)40-5-10-13(28)15(30)19(42-10)26-3-1-2-9(4-26)21(31)32/h1-4,7-8,10-11,13-16,19-20,28-30H,5-6H2,(H6-,22,23,24,31,32,33,34,35,36,37,38,39)/p+1/t10-,11-,13-,14-,15-,16-,19-,20-/m1/s1;   InChIKey=QOTXBMGJKFVZRD-HISDBWNOSA-O;   NAADP;   NAADP(1+);   SMILES=Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)[n+]2cccc(c2)C(O)=O)[C@@H](O)[C@H]1OP(O)(O)=O;   nicotinic acid-adenine dinucleotide phosphate(1+)
 alt_id: CHEBI:31906
 xref: CAS:5502-96-5;   KEGG:C13051;   KNApSAcK:C00007537
 xref_mesh: MESH:C024376
 xref: MetaCyc:CPD-15009;   PDBeChem:DN4;   PMID:11829748;   PMID:16690024;   PMID:21610076;   PMID:21664355;   PMID:21967541;   PMID:22117075;   PMID:22117077;   PMID:22260682;   PMID:22453949;   PMID:22534131;   PMID:22677461;   PMID:22822066;   PMID:22851169;   PMID:22988879;   PMID:22995315;   PMID:23177620;   PMID:23443655;   PMID:23467410;   PMID:23564460;   PMID:23634879;   PMID:23713141;   PMID:23763317;   Reaxys:9981819
 cyclic_relationship: is_conjugate_acid_of CHEBI:75967


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nicotinic acid-adenine dinucleotide phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd38 CD38 molecule multiple interactions ISO CD38 gene mutant form inhibits the reaction [FASL protein results in increased abundance of NAADP]; CD38 gene mutant form inhibits the reaction [NADP promotes the reaction [FASL protein results in increased abundance of NAADP]]; CD38 gene mutant form promotes the reaction [Niacinamide inhibits the reaction [NADP promotes the reaction [FASL protein results in increased abundance of NAADP]]] CTD PMID:20200208 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Edn1 endothelin 1 increases metabolic processing
multiple interactions		 ISO EDN1 protein results in increased metabolism of NAADP
NOX1 mutant form inhibits the reaction [EDN1 protein results in increased metabolism of NAADP]		 CTD PMID:23940720 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Faslg Fas ligand multiple interactions
increases abundance		 ISO CD38 gene mutant form inhibits the reaction [FASL protein results in increased abundance of NAADP]; CD38 gene mutant form inhibits the reaction [NADP promotes the reaction [FASL protein results in increased abundance of NAADP]]; CD38 gene mutant form promotes the reaction [Niacinamide inhibits the reaction [NADP promotes the reaction [FASL protein results in increased abundance of NAADP]]]; NADP promotes the reaction [FASL protein results in increased abundance of NAADP]; Niacinamide inhibits the reaction [NADP promotes the reaction [FASL protein results in increased abundance of NAADP]] CTD PMID:20200208 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Mcoln1 mucolipin TRP cation channel 1 increases activity
multiple interactions		 ISO NAADP results in increased activity of MCOLN1 protein
[NAADP results in increased activity of MCOLN1 protein] which affects the localization of Calcium		 CTD PMID:21613607 NCBI chr12:1,560,341...1,574,252
Ensembl chr12:1,560,359...1,574,252 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO NOX1 mutant form inhibits the reaction [EDN1 protein results in increased metabolism of NAADP] CTD PMID:23940720 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          metabolite 19484
            nicotinic acid-adenine dinucleotide phosphate 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      chalcogen 19513
                        oxygen atom 19488
                          oxygen molecular entity 19488
                            hydroxides 19299
                              oxoacid 18736
                                pnictogen oxoacid 13211
                                  phosphorus oxoacid 12414
                                    phosphoric acids 11418
                                      phosphoric acid 11418
                                        phosphoric acid derivative 11227
                                          phosphate 11226
                                            organic phosphate 11226
                                              nucleoside phosphate 1846
                                                nucleotide 1843
                                                  pyridine nucleotide 212
                                                    nicotinamide nucleotide 212
                                                      nicotinamide dinucleotide 190
                                                        NAD(P) 190
                                                          NAD(P)(+) 190
                                                            NADP(+) 122
                                                              nicotinic acid-adenine dinucleotide phosphate 5
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