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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Ponicidin
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Accession:CHEBI:67671 term browser browse the term
Definition:A dioxane that has formula C20H26O6.
Synonyms:related_synonym: (1-alpha,6-beta,7-alpha,14S,20S)-7,20:14,20-Diepoxy-1,6,7-trihydroxy-ent-kaur-16-en-15-one;   Formula=C20H26O6;   InChI=1S/C20H26O6/c1-8-9-4-5-10-18-11(21)6-7-17(2,3)12(18)14(23)20(24)19(10,13(8)22)15(9)25-16(18)26-20/h9-12,14-16,21,23-24H,1,4-7H2,2-3H3/t9-,10+,11+,12-,14+,15+,16+,18+,19+,20-/m1/s1;   InChIKey=WHRDRHNMTIXZNY-OSMZMOMSSA-N;   Rubescensin B;   SMILES=[H][C@]12CC[C@@]3([H])[C@]45[C@@H](O)CCC(C)(C)[C@@]4([H])[C@H](O)[C@@]4(O)O[C@]5([H])O[C@]1([H])[C@@]34C(=O)C2=C
 xref: CAS:52617-37-5;   PMID:21534539


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Ponicidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Ponicidin increases expression of BAX protein in the stomach RGD PMID:25588213 RGD:127285620 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Ponicidin decreases expression of BCL2 protein in the stomach RGD PMID:25588213 RGD:127285620 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases expression ISO Ponicidin increases expression of CASP3 protein in the stomach RGD PMID:25588213 RGD:127285620 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO Ponicidin decreases phosphorylation of JAK2 protein in the stomach RGD PMID:25588213 RGD:127285620 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kdr kinase insert domain receptor decreases expression ISO Ponicidin decreases expression of KDR protein in the stomach RGD PMID:25588213 RGD:127285620 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Ponicidin decreases phosphorylation of STAT3 protein in the stomach RGD PMID:25588213 RGD:127285620 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Ponicidin decreases expression of VEGFA protein in the stomach RGD PMID:25588213 RGD:127285620 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          metabolite 19484
            Ponicidin 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organic heteromonocyclic compound 17773
                                    dioxanes 61
                                      Ponicidin 7
paths to the root