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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,4-bis(2-ethylhexyl) sulfosuccinate
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Accession:CHEBI:534 term browser browse the term
Definition:A succinate ester that has formula C20H38O7S.
Synonyms:related_synonym: 1,4-bis(2-ethylhexoxy)-1,4-bis(oxidanylidene)butane-2-sulfonic acid;   1,4-bis(2-ethylhexoxy)-1,4-diketo-butane-2-sulfonic acid;   1,4-bis(2-ethylhexoxy)-1,4-dioxo-2-butanesulfonic acid;   1,4-bis(2-ethylhexoxy)-1,4-dioxo-butane-2-sulfonic acid;   1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonic acid;   1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonic acid;   1-(2-Methylphenyl)ethanone;   1-(2-Tolyl)ethanone;   1-(Methylphenyl)-Ethanone;   1-(Methylphenyl)ethan-1-one;   2'-Methyl-Acetophenone;   2'-Methylacetophenone;   2'-Methylacetylphenone;   2-Acetyltoluene;   Acetophenone, 2'-methyl- (8CI);   Docusate hydrogen;   Ethanone, 1-(2-methylphenyl)- (9CI);   Formula=C20H38O7S;   InChI=1S/C20H38O7S/c1-5-9-11-16(7-3)14-26-19(21)13-18(28(23,24)25)20(22)27-15-17(8-4)12-10-6-2/h16-18H,5-15H2,1-4H3,(H,23,24,25);   InChIKey=HNSDLXPSAYFUHK-UHFFFAOYSA-N;   Methyl O-tolyl ketone;   O-Acetyltoluene;   O-Methyl acetophenone;   O-Methylacetophenone;   SMILES=CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)S(O)(=O)=O;   dioctyl disodium sulfosuccinate;   dioctyl sulfosuccinate;   dioctyl sulfosuccinic acid;   docusate;   docusate calcium
 xref: CAS:10041-19-7;   CAS:577-16-2;   Drug_Central:941;   HMDB:HMDB0032386;   KEGG:C07874
 xref_mesh: MESH:D004143
 xref: PMID:19167006


show annotations for term's descendants           Sort by:
1,4-bis(2-ethylhexyl) sulfosuccinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression
multiple interactions		 ISO Dioctyl Sulfosuccinic Acid results in decreased expression of ADIPOQ mRNA
Dioctyl Sulfosuccinic Acid results in decreased expression of and results in decreased secretion of ADIPOQ protein		 CTD PMID:30728429 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 decreases expression ISO Dioctyl Sulfosuccinic Acid results in decreased expression of DLK1 mRNA CTD PMID:26135921 NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO Dioctyl Sulfosuccinic Acid results in increased expression of FABP4 mRNA CTD PMID:26135921 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Il6 interleukin 6 decreases methylation
multiple interactions		 ISO Dioctyl Sulfosuccinic Acid results in decreased methylation of IL6 promoter
Dioctyl Sulfosuccinic Acid results in increased expression of and results in increased secretion of IL6 protein		 CTD PMID:30728429 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO Dioctyl Sulfosuccinic Acid inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319 		JBrowse link
G Lep leptin increases expression
multiple interactions		 ISO Dioctyl Sulfosuccinic Acid results in increased expression of LEP mRNA
Dioctyl Sulfosuccinic Acid results in increased expression of and results in increased secretion of LEP protein		 CTD PMID:30728429 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression ISO Dioctyl Sulfosuccinic Acid results in increased expression of NOX4 mRNA CTD PMID:30728429 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity ISO Dioctyl Sulfosuccinic Acid results in increased activity of PPARA protein CTD PMID:26135921 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases activity ISO Dioctyl Sulfosuccinic Acid results in increased activity of PPARD protein CTD PMID:26135921 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases activity		 ISO Dioctyl Sulfosuccinic Acid binds to and results in increased activity of PPARG protein
Dioctyl Sulfosuccinic Acid results in increased activity of PPARG protein		 CTD PMID:26135921 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
decreases methylation		 ISO Dioctyl Sulfosuccinic Acid results in increased expression of PTGS2 mRNA
Dioctyl Sulfosuccinic Acid results in decreased methylation of PTGS2 promoter		 CTD PMID:30728429 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      group 19765
        inorganic group 19360
          sulfo group 9904
            organosulfonic acid 9904
              1,4-bis(2-ethylhexyl) sulfosuccinate 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      chalcogen 19513
                        oxygen atom 19488
                          oxygen molecular entity 19488
                            hydroxides 19299
                              oxoacid 18736
                                chalcogen oxoacid 13754
                                  sulfur oxoacid 13542
                                    sulfonic acid 11577
                                      sulfo group 9904
                                        organosulfonic acid 9904
                                          1,4-bis(2-ethylhexyl) sulfosuccinate 11
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