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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:all-trans-acitretin
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Accession:CHEBI:50173 term browser browse the term
Definition:An acitretin that has formula C21H26O3.
Synonyms:exact_synonym: (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
 related_synonym: (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid;   Acitretina;   Acitretine;   Acitretinum;   Etretin;   Formula=C21H26O3;   InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+;   InChIKey=IHUNBGSDBOWDMA-AQFIFDHZSA-N;   Neotigason;   SMILES=COc1cc(C)c(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(O)=O)c(C)c1C;   Soriatane;   acitretin;   all-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoic acid
 xref: Beilstein:2458933;   CAS:55079-83-9;   DrugBank:DB00459;   Drug_Central:78;   KEGG:D02754
 xref_mesh: MESH:D017255
 xref: Patent:DE2414619;   Patent:US4105681;   Wikipedia:Acitretin


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all-trans-acitretin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Acitretin results in increased expression of BAX protein CTD PMID:16109552 PMID:16196285 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Acitretin results in decreased expression of BCL2 protein CTD PMID:16109552 PMID:16196285 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity ISO Acitretin results in increased activity of CASP3 protein CTD PMID:16196285 PMID:18624760 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO Acitretin results in increased activity of CASP8 protein CTD PMID:18624760 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO Acitretin results in increased activity of CASP9 protein CTD PMID:18624760 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Acitretin results in decreased expression of CCND1 mRNA; Acitretin results in decreased expression of CCND1 protein CTD PMID:16610086 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Acitretin results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO Acitretin results in increased expression of FADD CTD PMID:18624760 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Acitretin results in increased expression of FAS CTD PMID:18624760 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression ISO Acitretin results in increased expression of FASLG CTD PMID:18624760 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression ISO Acitretin results in decreased expression of MAPK1 mRNA CTD PMID:16610086 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression ISO Acitretin results in decreased expression of MAPK3 mRNA CTD PMID:16610086 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Acitretin promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases activity ISO Acitretin results in increased activity of PARP1 protein CTD PMID:18624760 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO Acitretin binds to RXRA protein CTD PMID:31566444 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Slc25a5 solute carrier family 25 member 5 decreases expression EXP Acitretin results in decreased expression of SLC25A5 protein CTD PMID:23384448 NCBI chr  X:116,031,896...116,034,963
Ensembl chr  X:116,031,803...116,034,967 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression ISO Acitretin results in decreased expression of STAT3 mRNA; Acitretin results in decreased expression of STAT3 protein; Acitretin results in decreased expression of STAT3 protein modified form CTD PMID:16610086 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Acitretin promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
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  CHEBI ontology 19808
    role 19784
      application 19627
        pharmaceutical 19468
          drug 19468
            dermatologic drug 13612
              keratolytic drug 10659
                all-trans-acitretin 18
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  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            organic hydride 18669
                              organic fundamental parent 18669
                                hydrocarbon 18415
                                  terpene 14057
                                    diterpene 13024
                                      diterpenoid 13024
                                        retinoid 10272
                                          acitretin 18
                                            all-trans-acitretin 18
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