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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:estazolam
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Accession:CHEBI:4858 term browser browse the term
Definition:A triazolo[4,3-a][1,4]benzodiazepine having a phenyl group at position 6 and a chloro substituent at position 8. A short-acting benzodiazepine with general properties similar to diazepam, it is given by mouth as a hypnotic in the short-term management of insomnia.
Synonyms:exact_synonym: 8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
 related_synonym: 8-chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine;   Formula=C16H11ClN4;   InChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2;   InChIKey=CDCHDCWJMGXXRH-UHFFFAOYSA-N;   SMILES=Clc1ccc-2c(c1)C(=NCc1nncn-21)c1ccccc1;   estazolamum
 alt_id: CHEBI:149847
 xref: Beilstein:1220868;   CAS:29975-16-4;   DrugBank:DB01215;   Drug_Central:1056;   KEGG:D00311
 xref_mesh: MESH:D004949
 xref: PMID:7154007;   Patent:DE1955349;   Patent:DE2012190;   Patent:DE2114441;   Patent:US3701782;   Wikipedia:Estazolam


show annotations for term's descendants           Sort by:
estazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Estazolam results in decreased activity of AKR1C1 protein CTD PMID:11995921 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Estazolam results in decreased activity of AKR1C2 protein CTD PMID:11995921 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Estazolam results in decreased activity of AKR1C3 protein CTD PMID:11995921 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation ISO CYP3A4 protein results in increased hydroxylation of Estazolam CTD PMID:16012077 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Estazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637 		JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Estazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biophysical role 14037
          membrane transport modulator 13879
            GABA modulator 5105
              estazolam 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  heteroarene 17117
                                    monocyclic heteroarene 14853
                                      azole 14358
                                        triazoles 8124
                                          estazolam 6
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