CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: all-trans-4-oxoretinol
Accession: CHEBI:44597
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Definition: A retinoid that is all-trans-retinol in which the hydrogens at position 4 have been replaced by an oxo group.
Synonyms: related_synonym: 4-ketoretinol; 4-oxo-ROL; 4-oxoretinol; Formula=C20H28O2; InChI=1S/C20H28O2/c1-15(7-6-8-16(2)12-14-21)9-10-18-17(3)19(22)11-13-20(18,4)5/h6-10,12,21H,11,13-14H2,1-5H3/b8-6+,10-9+,15-7+,16-12+; InChIKey=PLIUCYCUYQIBDZ-RMWYGNQTSA-N; SMILES=C1(=C(C(CCC1(C)C)=O)C)/C=C/C(=C/C=C/C(=C/CO)/C)/C
xref: CAS:62702-55-0; DrugBank:DB02699; HMDB:HMDB0012329; KEGG:C16683
xref_mesh: MESH:C041819
xref: PDBeChem:OXR; PMID:10415093; PMID:10557354; PMID:15817863; PMID:17943179; PMID:18006143; PMID:19492420; PMID:24662164; PMID:8643497; PMID:9377581; PMID:9581846; Patent:US6150421; Reaxys:14831438
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Cdh1
cadherin 1
affects expression
ISO
4-oxoretinol affects the expression of CDH1 mRNA
CTD
PMID:17034753
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Col1a1
collagen type I alpha 1 chain
increases expression
ISO
4-oxoretinol results in increased expression of COL1A1 mRNA
CTD
PMID:17034753
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col4a2
collagen type IV alpha 2 chain
increases expression
ISO
4-oxoretinol results in increased expression of COL4A2 mRNA
CTD
PMID:17034753
NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839
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Crabp2
cellular retinoic acid binding protein 2
increases expression
ISO
4-oxoretinol results in increased expression of CRABP2 mRNA
CTD
PMID:17034753
NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
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Cyp26a1
cytochrome P450, family 26, subfamily a, polypeptide 1
affects chemical synthesis
ISO
CYP26A1 protein affects the chemical synthesis of 4-oxoretinol
CTD
PMID:10557354
NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
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Fas
Fas cell surface death receptor
decreases expression
ISO
4-oxoretinol results in decreased expression of FAS mRNA
CTD
PMID:17034753
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Foxa1
forkhead box A1
increases expression
ISO
4-oxoretinol results in increased expression of FOXA1 mRNA
CTD
PMID:17034753
NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
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Gata6
GATA binding protein 6
increases expression
ISO
4-oxoretinol results in increased expression of GATA6 mRNA
CTD
PMID:17034753
NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
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Itgam
integrin subunit alpha M
increases expression
ISO
4-oxoretinol results in increased expression of ITGAM protein
CTD
PMID:9581846
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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Ivl
involucrin
increases expression
ISO
4-oxoretinol results in increased expression of IVL mRNA
CTD
PMID:17034753
NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
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Krt18
keratin 18
increases expression
ISO
4-oxoretinol results in increased expression of KRT18 mRNA
CTD
PMID:17034753
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
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Krt19
keratin 19
increases expression
ISO
4-oxoretinol results in increased expression of KRT19 mRNA
CTD
PMID:17034753
NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
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Krt7
keratin 7
increases expression
ISO
4-oxoretinol results in increased expression of KRT7 mRNA
CTD
PMID:17034753
NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052
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Krt8
keratin 8
increases expression
ISO
4-oxoretinol results in increased expression of KRT8 mRNA
CTD
PMID:17034753
NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
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Mcl1
MCL1 apoptosis regulator, BCL2 family member
decreases expression
ISO
4-oxoretinol results in decreased expression of MCL1 mRNA
CTD
PMID:17034753
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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Meis1
Meis homeobox 1
increases expression
ISO
4-oxoretinol results in increased expression of MEIS1 mRNA
CTD
PMID:17034753
NCBI chr14:93,155,426...93,294,373
Ensembl chr14:93,155,419...93,294,265
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Meis2
Meis homeobox 2
increases expression
ISO
4-oxoretinol results in increased expression of MEIS2 mRNA
CTD
PMID:17034753
NCBI chr 3:102,742,904...102,944,833
Ensembl chr 3:102,742,900...102,949,696
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Meox1
mesenchyme homeobox 1
increases expression
ISO
4-oxoretinol results in increased expression of MEOX1 mRNA
CTD
PMID:17034753
NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660
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Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
increases expression
ISO
4-oxoretinol results in increased expression of MUC5AC mRNA
CTD
PMID:17034753
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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Olr1
oxidized low density lipoprotein receptor 1
increases expression
ISO
4-oxoretinol results in increased expression of OLR1 mRNA
CTD
PMID:17034753
NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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Rara
retinoic acid receptor, alpha
increases expression
ISO
4-oxoretinol results in increased expression of RARA mRNA
CTD
PMID:17034753
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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Rarres1
retinoic acid receptor responder 1
increases expression
ISO
4-oxoretinol results in increased expression of RARRES1 mRNA
CTD
PMID:17034753
NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978
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Tgm2
transglutaminase 2
increases expression
ISO
4-oxoretinol results in increased expression of TGM2 mRNA
CTD
PMID:17034753
NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
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