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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:propiophenone
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Accession:CHEBI:425902 term browser browse the term
Definition:An aromatic ketone in which the two substituents on the carbonyl C atom are phenyl and ethyl.
Synonyms:related_synonym: 1-Phenyl-1-propanone;   1-Phenyl-propan-1-one;   1-phenylpropan-1-one;   Ethyl phenyl ketone;   Formula=C9H10O;   InChI=1S/C9H10O/c1-2-9(10)8-6-4-3-5-7-8/h3-7H,2H2,1H3;   InChIKey=KRIOVPPHQSLHCZ-UHFFFAOYSA-N;   Propionphenone;   Propionylbenzene;   SMILES=CCC(=O)c1ccccc1
 xref: Beilstein:606215;   CAS:93-55-0;   HMDB:HMDB0032623;   PDBeChem:I1E;   PMID:24302226;   Patent:CN101759540;   Reaxys:606215;   Wikipedia:Propiophenone


show annotations for term's descendants           Sort by:
2-aminopropiophenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a3 solute carrier family 6 member 3 decreases expression ISO cathinone analog results in decreased expression of SLC6A3 mRNA CTD PMID:28173643 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
mephedrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO mephedrone results in increased activity of CASP3 protein CTD PMID:32382956 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases expression
increases expression		 EXP
ISO		 mephedrone results in decreased expression of CAT protein
mephedrone results in increased expression of CAT protein		 CTD PMID:25817894 PMID:26747301 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 affects expression EXP mephedrone affects the expression of CCL2 protein CTD PMID:34742947 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Drd2 dopamine receptor D2 decreases expression EXP mephedrone results in decreased expression of DRD2 protein CTD PMID:25817894 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
increases expression		 EXP
ISO		 mephedrone results in decreased expression of GPX1 protein
mephedrone results in increased expression of GPX1 protein		 CTD PMID:25817894 PMID:26747301 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Il1a interleukin 1 alpha affects expression EXP mephedrone affects the expression of IL1A protein CTD PMID:34742947 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta affects expression EXP mephedrone affects the expression of IL1B protein CTD PMID:34742947 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 affects expression EXP mephedrone affects the expression of IL6 protein CTD PMID:34742947 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nos1 nitric oxide synthase 1 affects expression EXP mephedrone affects the expression of NOS1 protein CTD PMID:25817894 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression
multiple interactions		 EXP
ISO		 mephedrone results in decreased expression of SLC6A3 protein
Ethanol promotes the reaction [mephedrone results in decreased expression of SLC6A3 protein]		 CTD PMID:25817894 PMID:26747301 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions
decreases expression		 ISO
EXP		 Ethanol promotes the reaction [mephedrone results in decreased expression of SLC6A4 protein] CTD PMID:25817894 PMID:26747301 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Sod1 superoxide dismutase 1 affects expression EXP mephedrone affects the expression of SOD1 protein CTD PMID:25817894 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Th tyrosine hydroxylase multiple interactions
decreases expression		 ISO
EXP		 Ethanol promotes the reaction [mephedrone results in decreased expression of TH protein] CTD PMID:25817894 PMID:26747301 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor affects expression EXP mephedrone affects the expression of TNF protein CTD PMID:34742947 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tph2 tryptophan hydroxylase 2 multiple interactions
decreases expression		 ISO
EXP		 Ethanol promotes the reaction [mephedrone results in decreased expression of TPH2 protein] CTD PMID:25817894 PMID:26747301 NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        fragrance 998
          propiophenone 15
            2,3-diacetoxypropioveratrone 0
            2-aminopropiophenone + 1
            2-hydroxy-1-phenyl-1-propanone 0
            4-methylpropiophenone 0
            diethylpropion + 0
            mephedrone 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbonyl compound 18869
                                    ketone 17165
                                      aromatic ketone 12447
                                        propiophenone 15
                                          2,3-diacetoxypropioveratrone 0
                                          2-aminopropiophenone + 1
                                          2-hydroxy-1-phenyl-1-propanone 0
                                          4-methylpropiophenone 0
                                          diethylpropion + 0
                                          mephedrone 15
paths to the root