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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cucurbitacin E
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Accession:CHEBI:3944 term browser browse the term
Definition:A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23.
Synonyms:exact_synonym: (4R,23E)-2,16alpha,20-trihydroxy-9beta,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-2,5,23-trien-25-yl acetate
 related_synonym: (23E)-25-acetyloxy-2,16alpha,20-trihydroxy-9beta-methyl-19-nor-10alpha-lanosta-1,5,23-triene-3,11,22-trione;   2,16alpha,20,25-tetrahydroxy-9-methyl-19-nor-9beta,10alpha-lanosta-1,5,23-triene-3,11,22-trione 25-acetate;   Formula=C32H44O8;   InChI=1S/C32H44O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-14,19,21-22,25,34-35,39H,11,15-16H2,1-9H3/b13-12+/t19-,21-,22+,25+,29+,30-,31+,32+/m1/s1;   InChIKey=NDYMQXYDSVBNLL-MUYMLXPFSA-N;   SMILES=[H][C@@]12CC=C3[C@@]([H])(C=C(O)C(=O)C3(C)C)[C@]1(C)C(=O)C[C@]1(C)[C@]([H])([C@H](O)C[C@@]21C)[C@@](C)(O)C(=O)\\C=C\\C(C)(C)OC(C)=O;   alpha-Elaterin;   alpha-Elaterine
 xref: Beilstein:2343323;   CAS:18444-66-1;   KEGG:C08797;   KNApSAcK:C00003686;   LIPID_MAPS_instance:LMST01010107
 xref_mesh: MESH:C102326
 xref: PMID:13611647;   PMID:15908139;   PMID:19177898;   PMID:19816711;   PMID:20110807;   PMID:20347305;   PMID:4384331;   Reaxys:2343323


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cucurbitacin E term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 EXP
ISO		 cucurbitacin E results in decreased expression of ACTA2 mRNA; cucurbitacin E results in decreased expression of ACTA2 protein
cucurbitacin E inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]		 CTD PMID:27363783 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
affects phosphorylation		 ISO Acetylcysteine inhibits the reaction [cucurbitacin E affects the phosphorylation of AKT1 protein] CTD PMID:27106530 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO
EXP		 cucurbitacin E results in increased expression of BAX protein CTD PMID:27106530 PMID:27363783 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO
EXP		 cucurbitacin E results in decreased expression of BCL2 protein CTD PMID:27106530 PMID:27363783 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO cucurbitacin E results in decreased expression of BCL2L1 protein CTD PMID:27106530 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO Acetylcysteine inhibits the reaction [cucurbitacin E results in increased expression of and results in increased phosphorylation of BECN1 protein]; cucurbitacin E results in increased expression of and results in increased phosphorylation of BECN1 protein CTD PMID:27106530 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO
EXP		 acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cucurbitacin E results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of CASP3 protein] CTD PMID:27106530 PMID:27363783 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases cleavage		 ISO acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cucurbitacin E results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of CASP7 protein] CTD PMID:27106530 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO cucurbitacin E results in increased cleavage of CASP9 protein CTD PMID:27106530 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP cucurbitacin E results in decreased expression of COL1A1 mRNA CTD PMID:27363783 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP cucurbitacin E results in decreased phosphorylation of MAPK1 protein CTD PMID:27363783 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP cucurbitacin E results in decreased phosphorylation of MAPK3 protein CTD PMID:27363783 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation		 ISO
EXP		 Acetylcysteine inhibits the reaction [cucurbitacin E results in decreased phosphorylation of MTOR protein]
cucurbitacin E inhibits the reaction [Thioacetamide results in increased phosphorylation of MTOR protein]		 CTD PMID:27106530 PMID:27363783 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO
EXP		 acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cucurbitacin E results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of PARP1 protein] CTD PMID:27106530 PMID:27363783 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO cucurbitacin E results in increased expression of and results in increased phosphorylation of PTEN protein CTD PMID:27106530 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation		 ISO
EXP		 cucurbitacin E inhibits the reaction [Thioacetamide results in increased phosphorylation of RPS6KB1 protein]
cucurbitacin E results in decreased phosphorylation of RPS6KB1 protein		 CTD PMID:27363783 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [cucurbitacin E results in increased expression of SQSTM1 protein] CTD PMID:27106530 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression		 ISO
EXP		 cucurbitacin E inhibits the reaction [Thioacetamide results in increased expression of TIMP1 protein]
cucurbitacin E results in decreased expression of TIMP1 mRNA; cucurbitacin E results in decreased expression of TIMP1 protein		 CTD PMID:27363783 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions ISO Acetylcysteine inhibits the reaction [cucurbitacin E results in decreased expression of and results in decreased phosphorylation of ULK1 protein]; cucurbitacin E results in decreased expression of and results in decreased phosphorylation of ULK1 protein CTD PMID:27106530 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          metabolite 19484
            allelochemical 1384
              cucurbitacin 49
                cucurbitacin E 19
                  cucurbitacin E 2-O-beta-D-glucopyranoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbonyl compound 18869
                                    ketone 17165
                                      oxyketone 8901
                                        alpha-oxyketone 8901
                                          alpha-hydroxy ketone 8901
                                            tertiary alpha-hydroxy ketone 8608
                                              cucurbitacin E 19
                                                cucurbitacin E 2-O-beta-D-glucopyranoside 0
paths to the root