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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:malonate ester
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Accession:CHEBI:38083 term browser browse the term
Definition:An ester of malonic acid; any compound containing a malonate ester skeleton.
Synonyms:related_synonym: malonate;   malonate esters;   malonates


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isoprothiolane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO isoprothiolane results in increased expression of CYP3A4 mRNA CTD PMID:17293382 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression		 ISO isoprothiolane binds to and results in increased activity of ESR1 protein
isoprothiolane results in decreased expression of ESR1 protein		 CTD PMID:17904202 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO isoprothiolane binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pgr progesterone receptor increases expression ISO isoprothiolane results in increased expression of PGR mRNA CTD PMID:17904202 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO isoprothiolane results in increased expression of TFF1 mRNA CTD PMID:17904202 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    chemical entity 19842
      group 19800
        inorganic group 19395
          oxo group 18890
            organic oxo compound 18890
              carbonyl compound 18890
                carboxylic ester 16740
                  malonate ester 5
                    6-O-malonyl-trans-rhaponticin 0
                    6alpha-malonyloxymanoyl oxide 0
                    brasilinolide A 0
                    formononetin 7-O-glucoside-6''-O-malonate 0
                    isoprothiolane + 5
                    luteolin 7-O-(6-O-malonyl-beta-D-glucoside) 0
                    malonylapiin 0
                    malonyldaidzin 0
                    malonylgenistin 0
                    malonylglycitin 0
                    quercetin 3-O-(6-O-malonyl-beta-D-glucoside) 0
                    tosylmalonate ester + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            heteroorganic entity 19486
                              organochalcogen compound 19249
                                organooxygen compound 19167
                                  carbonyl compound 18890
                                    dicarboxylic acids and O-substituted derivatives 11080
                                      dicarboxylic acid 11074
                                        alpha,omega-dicarboxylic acid 3140
                                          malonic acid 62
                                            malonate ester 5
                                              6-O-malonyl-trans-rhaponticin 0
                                              6alpha-malonyloxymanoyl oxide 0
                                              brasilinolide A 0
                                              formononetin 7-O-glucoside-6''-O-malonate 0
                                              isoprothiolane + 5
                                              luteolin 7-O-(6-O-malonyl-beta-D-glucoside) 0
                                              malonylapiin 0
                                              malonyldaidzin 0
                                              malonylgenistin 0
                                              malonylglycitin 0
                                              quercetin 3-O-(6-O-malonyl-beta-D-glucoside) 0
                                              tosylmalonate ester + 0
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