tetrachloro-1,4-benzoquinone - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	tetrachloro-1,4-benzoquinone	go back to main search page
Accession:	CHEBI:36703	browse the term
Definition:	A member of the class of 1,4-benzoquiones that is 1,4-benzoquinone in which all four hydrogens are substituted by chlorines.
Synonyms:	exact_synonym:	2,3,5,6-tetrachlorocyclohexa-2,5-diene-1,4-dione
	related_synonym:	2,3,5,6-Tetrachlor-1,4-benzochinon; 2,3,5,6-tetrachloro-1,4-benzoquinone; 2,3,5,6-tetrachloro-2,5-cyclohexadiene-1,4-dione; 2,3,5,6-tetrachloro-p-benzoquinone; 2,3,5,6-tetrachlorobenzo-1,4-quinone; Formula=C6Cl4O2; InChI=1S/C6Cl4O2/c7-1-2(8)6(12)4(10)3(9)5(1)11; InChIKey=UGNWTBMOAKPKBL-UHFFFAOYSA-N; SMILES=ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O; alpha-chloranil; chloranil; p-Chloranil; tetrachloro-p-benzoquinone; tetrachlorobenzoquinone; tetrachloroparabenzoquinone
	xref:	Beilstein:393006; CAS:118-75-2; Gmelin:50924; KEGG:C18933
	xref_mesh:	MESH:D002703
	xref:	PMID:11864786; PMID:19408893; PMID:20797618; PPDB:1297

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Genes (19)

tetrachloro-1,4-benzoquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases activity

Chloranil results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions
decreases activity

Curcumin inhibits the reaction [Chloranil results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

endothelial cell-specific molecule 1

increases expression

Chloranil results in increased expression of ESM1 mRNA

NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804

G

F-box protein 32

increases expression

Chloranil results in increased expression of FBXO32 mRNA

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

G

ferritin light chain 1

multiple interactions
increases expression

[Chloranil results in increased abundance of 5-hydroxymethylcytosine] which results in increased expression of FTL mRNA
Chloranil results in increased expression of FTL mRNA; Chloranil results in increased expression of FTL protein

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725

G

golgi SNAP receptor complex member 2

increases expression

Chloranil results in increased expression of GOSR2 mRNA

NCBI chr10:88,585,291...88,605,642
Ensembl chr10:88,586,299...88,605,625

G

glutamic--pyruvic transaminase

increases activity
multiple interactions

Chloranil results in increased activity of GPT protein
Curcumin inhibits the reaction [Chloranil results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

heme oxygenase 1

multiple interactions
increases expression

[Curcumin co-treated with Chloranil] results in increased expression of HMOX1 protein
Chloranil results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 1 beta

increases expression
multiple interactions

Chloranil results in increased expression of IL1B protein
Curcumin inhibits the reaction [Chloranil results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression
multiple interactions

Chloranil results in increased expression of IL6 protein
Curcumin inhibits the reaction [Chloranil results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

nitric oxide synthase 2

increases expression
multiple interactions

Chloranil results in increased expression of NOS2 protein
Curcumin inhibits the reaction [Chloranil results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

Chloranil results in increased expression of NQO1 protein
[Curcumin co-treated with Chloranil] results in increased expression of NQO1 protein

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

Chloranil results in increased expression of PTGS2 protein
Curcumin inhibits the reaction [Chloranil results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
affects localization
increases expression

Curcumin inhibits the reaction [Chloranil affects the localization of RELA protein modified form]; Curcumin inhibits the reaction [Chloranil results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

Rho family GTPase 3

increases expression

Chloranil results in increased expression of RND3 mRNA

NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327

G

tet methylcytosine dioxygenase 1

multiple interactions

TET1 protein affects the reaction [Chloranil results in increased chemical synthesis of 5-hydroxymethylcytosine]; TET1 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine]

NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052

G

tet methylcytosine dioxygenase 2

multiple interactions

TET2 protein affects the reaction [Chloranil results in increased chemical synthesis of 5-hydroxymethylcytosine]; TET2 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine]

NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534

G

tumor necrosis factor

increases expression

Chloranil results in increased expression of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

ubiquitin C

increases expression
multiple interactions

Chloranil results in increased expression of UBC mRNA
[Chloranil results in increased abundance of 5-hydroxymethylcytosine] which results in increased expression of UBC mRNA

NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19808
role	19784
biological role	19782
biochemical role	19496
metabolite	19484
tetrachloro-1,4-benzoquinone	19
Path 2
Term	Annotations
CHEBI ontology	19808
subatomic particle	19806
composite particle	19806
hadron	19806
baryon	19806
nucleon	19806
atomic nucleus	19806
atom	19806
main group element atom	19756
p-block element atom	19756
carbon group element atom	19705
carbon atom	19702
organic molecular entity	19702
heteroorganic entity	19460
organochalcogen compound	19224
organooxygen compound	19141
carbonyl compound	18869
ketone	17165
cyclic ketone	15685
quinone	8644
benzoquinones	785
1,4-benzoquinones	782
tetrachloro-1,4-benzoquinone	19

paths to the root