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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cefaclor
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Accession:CHEBI:3478 term browser browse the term
Definition:A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.
Synonyms:exact_synonym: (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   7beta-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid;   CCL;   Cefaclor anhydrous;   Cephaclor;   Formula=C15H14ClN3O4S;   InChI=1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1;   InChIKey=QYIYFLOTGYLRGG-GPCCPHFNSA-N;   SMILES=[H][C@]12SCC(Cl)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccccc1)C(O)=O;   cefaclorum
 alt_id: CHEBI:472656
 xref: Beilstein:3632473;   CAS:53994-73-3;   DrugBank:DB00833;   Drug_Central:525;   HMDB:HMDB0014971;   KEGG:C06877;   KEGG:D00256;   LINCS:LSM-5368
 xref_mesh: MESH:D002433
 xref: PMID:10230635;   PMID:10930630;   PMID:11963587;   PMID:12485718;   PMID:12569987;   PMID:15812119;   PMID:18969055;   PMID:29017833;   Patent:DE2408698;   Patent:US3925372;   Reaxys:3632473;   Wikipedia:Cefaclor


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cefaclor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO Cefaclor inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Cefaclor results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Cefaclor results in increased expression of CYP3A4 mRNA; Cefaclor results in increased expression of CYP3A4 protein CTD PMID:18505790 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Cefaclor inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:16098483 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake
multiple interactions		 ISO SLC22A8 protein results in increased uptake of Cefaclor
Cefaclor inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]		 CTD PMID:16098483 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    role 19820
      biological role 19818
        antimicrobial agent 18191
          antibacterial agent 15640
            antibacterial drug 4423
              cefaclor 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            heteroorganic entity 19486
                              organochalcogen compound 19249
                                organooxygen compound 19167
                                  carbon oxoacid 18634
                                    carboxylic acid 18631
                                      carboacyl group 17703
                                        univalent carboacyl group 17703
                                          carbamoyl group 17554
                                            carboxamide 17554
                                              lactam 8390
                                                beta-lactam 830
                                                  beta-lactam antibiotic 815
                                                    cephem 551
                                                      cephalosporin 550
                                                        cefaclor 4
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