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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Lafutidine
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Accession:CHEBI:31759 term browser browse the term
Synonyms:related_synonym: FRG-8813;   Formula=C22H29N3O4S;   InChI=1S/C22H29N3O4S/c26-21(18-30(27)17-20-7-6-14-28-20)23-9-2-5-13-29-22-15-19(8-10-24-22)16-25-11-3-1-4-12-25/h2,5-8,10,14-15H,1,3-4,9,11-13,16-18H2,(H,23,26)/b5-2-;   InChIKey=KMZQAVXSMUKBPD-DJWKRKHSSA-N;   SMILES=C1CCN(CC1)CC2=CC(=NC=C2)OC/C=C\\CNC(CS(CC3=CC=CO3)=O)=O;   laflutidine;   protecadin
 xref: CAS:118288-08-7;   CAS:206449-93-6;   Drug_Central:1537;   HMDB:HMDB0240216;   KEGG:D01131
 xref_mesh: MESH:C076948


show annotations for term's descendants           Sort by:
Lafutidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha increases expression
multiple interactions		 ISO
EXP		 lafutidine results in increased expression of CALCA protein
CALCA protein modified form affects the susceptibility to [lafutidine co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide]		 CTD PMID:12542603 PMID:16416222 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP lafutidine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; lafutidine inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:10671773 PMID:15573930 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming multiple interactions EXP lafutidine inhibits the reaction [loxoprofen results in decreased expression of MUC2] CTD PMID:20586851 NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP lafutidine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; lafutidine inhibits the reaction [loxoprofen results in increased expression of NOS2] CTD PMID:10671773 PMID:20586851 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO lafutidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Sst somatostatin increases expression ISO lafutidine results in increased expression of SST protein CTD PMID:16416222 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects activity EXP lafutidine affects the activity of TRPV1 protein CTD PMID:18344609 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    chemical entity 19842
      atom 19842
        nonmetal atom 19780
          carbon atom 19734
            organic molecular entity 19734
              Lafutidine 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            Lafutidine 7
paths to the root