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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:steroid glucosiduronic acid
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Accession:CHEBI:26763 term browser browse the term
Synonyms:related_synonym: steroid glucosiduronic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:136637


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17beta-estradiol 17-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 increases uptake
multiple interactions		 ISO ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide
Adenosine Triphosphate affects the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Digoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; dofequidar inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; ochratoxin A inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Probenecid inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Verapamil inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]		 CTD PMID:12379217 NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
affects localization
decreases secretion		 EXP estradiol-17 beta-glucuronide results in decreased activity of ABCB11 protein
estradiol-17 beta-glucuronide affects the localization of and affects the activity of ABCB11 protein; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]
estradiol-17 beta-glucuronide results in decreased secretion of ABCB11 protein		 CTD PMID:10869290 PMID:12702498 PMID:12893835 PMID:15763547 PMID:18972403 More... NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
increases transport
multiple interactions		 ISO
EXP		 ABCB1 affects the susceptibility to estradiol-17 beta-glucuronide
ABCB1 results in increased transport of estradiol-17 beta-glucuronide
Daunorubicin inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]; estriol 17-glucuronide inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]; estriol-16 alpha-(beta-D-glucuronide) inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]		 CTD PMID:9794924 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 affects export ISO ABCB4 protein affects the export of estradiol-17 beta-glucuronide CTD PMID:11302927 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects transport
increases transport
increases uptake
multiple interactions
increases export		 ISO ABCC1 protein affects the transport of estradiol-17 beta-glucuronide
ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide; ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide
ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide
[Glutathione co-treated with Apigenin] affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; [Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide]; BAY u9773 inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; BAY u9773 inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; estradiol-17 beta-glucuronide inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein mutant form]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein]; estradiol-17 beta-glucuronide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; kaempferol affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Quercetin affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; S-decylglutathione inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; S-decylglutathione inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]
ABCC1 protein results in increased export of estradiol-17 beta-glucuronide		 CTD PMID:11278867 PMID:11306701 PMID:15459206 PMID:18336795 PMID:21918036 More... NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
multiple interactions
affects transport
affects response to substance
increases transport
affects localization
decreases secretion		 ISO
EXP		 ABCC2 protein affects the export of estradiol-17 beta-glucuronide
[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; [SLCO1B1 protein co-treated with ABCC2 protein] results in increased transport of estradiol-17 beta-glucuronide; [SLCO1B1 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; Bile Acids and Salts promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; estradiol-17 beta-glucuronide promotes the reaction [ABCC2 protein affects the transport of Bile Acids and Salts]; estradiol-17 beta-glucuronide results in decreased activity of and affects the localization of ABCC2 protein; Ethinyl Estradiol metabolite promotes the reaction [ABCC2 protein results in increased uptake of estradiol-17 beta-glucuronide]; Furosemide promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Indomethacin promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Pantoprazole promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Penicillin G promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; sulfanitran promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide]
ABCC2 protein affects the susceptibility to estradiol-17 beta-glucuronide
ABCC2 protein modified form results in increased transport of estradiol-17 beta-glucuronide; ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide
abietic acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]; AG 1879 inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; Bucladesine inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; CL 387785 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; EGF protein inhibits the reaction [Fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]]; EGFR protein promotes the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein; Fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; Glycyrrhetinic Acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Protein Kinase Inhibitors inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]
estradiol-17 beta-glucuronide results in decreased secretion of ABCC2 protein		 CTD PMID:11500505 PMID:12029626 PMID:12642476 PMID:12702498 PMID:12702717 More... NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 affects transport
increases activity
increases transport
multiple interactions		 ISO ABCC3 protein affects the transport of estradiol-17 beta-glucuronide
estradiol-17 beta-glucuronide results in increased activity of ABCC3 protein
ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide
Bile Acids and Salts inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Ethinyl Estradiol metabolite promotes the reaction [ABCC3 protein results in increased uptake of estradiol-17 beta-glucuronide]; Furosemide inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Indomethacin inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; resveratrol metabolite promotes the reaction [ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide]; resveratrol-4'-O-glucuronide inhibits the reaction [ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide]		 CTD PMID:12704183 PMID:14722317 PMID:17569508 PMID:19114588 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases transport
increases export
affects export		 ISO ABCC4 protein results in increased transport of estradiol-17 beta-glucuronide
ABCC4 protein results in increased export of estradiol-17 beta-glucuronide
ABCC4 gene SNP affects the export of estradiol-17 beta-glucuronide		 CTD PMID:11856762 PMID:27659809 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases transport
multiple interactions		 ISO ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide
Glycyrrhetinic Acid inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide]; lapatinib inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide]		 CTD PMID:18436619 PMID:18829547 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 EXP estradiol-17 beta-glucuronide results in increased phosphorylation of AKT1 protein
tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of AKT1 protein]		 CTD PMID:29090346 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aqp8 aquaporin 8 decreases expression EXP estradiol-17 beta-glucuronide results in decreased expression of AQP8 protein CTD PMID:17110522 NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP EGF protein inhibits the reaction [fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]] CTD PMID:25813982 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP EGFR protein promotes the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of EGFR protein; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:25813982 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions EXP estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of ESR1 protein CTD PMID:25813982 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions
increases uptake		 EXP [HGF protein results in increased expression of SLCO1A1 protein] which results in increased uptake of estradiol-17 beta-glucuronide; ochratoxin A inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; SLCO1A1 protein affects the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; Sulfobromophthalein inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:18031729 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
increases phosphorylation		 EXP 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of IGF1R protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein] CTD PMID:29090346 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Ocln occludin affects localization EXP estradiol-17 beta-glucuronide affects the localization of OCLN protein CTD PMID:17463180 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions
affects localization		 EXP Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of PRKCA protein] CTD PMID:18972403 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
affects transport		 EXP
ISO		 estradiol-17 beta-glucuronide inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]
SLC22A8 protein affects the transport of estradiol-17 beta-glucuronide		 CTD PMID:11306713 PMID:15319347 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects uptake
multiple interactions
increases uptake		 ISO
EXP		 SLCO1A4 protein affects the uptake of estradiol-17 beta-glucuronide
Bile Acids and Salts inhibits the reaction [SLCO1A2 protein results in increased uptake of estradiol-17 beta-glucuronide]		 CTD PMID:19464309 PMID:21561886 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 increases uptake
multiple interactions
affects response to substance
increases import		 EXP
ISO		 SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide
Bile Acids and Salts inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide]
SLCO1B2 protein affects the susceptibility to estradiol-17 beta-glucuronide
2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; pentabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide]		 CTD PMID:18180276 PMID:18296417 PMID:19464309 PMID:20176623 PMID:32003934 More... NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein; Protein Kinase Inhibitors inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein]; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein] CTD PMID:25813982 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tjp1 tight junction protein 1 affects localization EXP estradiol-17 beta-glucuronide affects the localization of TJP1 protein CTD PMID:17463180 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
17beta-estradiol 3-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity EXP estradiol-3-glucuronide results in decreased activity of ABCB11 protein CTD PMID:10869290 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Kl Klotho multiple interactions
increases hydrolysis		 ISO estradiol-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
KL protein results in increased hydrolysis of estradiol-3-glucuronide		 CTD PMID:14701853 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
Aldosterone 18-glucuronide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases chemical synthesis		 ISO alclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; cicloprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Diclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Diflunisal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Fenoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ibuprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Indomethacin inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ketoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ketorolac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Naproxen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; pirprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; tiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide] CTD PMID:19740398 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
androsterone 3-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho multiple interactions ISO androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
estriol 16-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP estriol-16 alpha-(beta-D-glucuronide) inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:9794924 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
estriol 3-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho multiple interactions
increases hydrolysis		 ISO estriol 3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
KL protein results in increased hydrolysis of estriol 3-glucuronide		 CTD PMID:14701853 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
estrone 3-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho increases hydrolysis
multiple interactions		 ISO KL protein results in increased hydrolysis of estrone-3-glucuronide
estrone-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]		 CTD PMID:14701853 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
testosterone 17-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho multiple interactions ISO testosterone glucuronate inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      atom 19806
        nonmetal atom 19744
          carbon atom 19702
            organic molecular entity 19702
              lipid 17957
                steroid 14678
                  steroid glucosiduronic acid 25
                    (2S,3S,4R,5S,6R)-6-(\{3-[(1R,3aS,3bR,9aR,9bS,11aS)-1-hydroxy-9a,11a-dimethyl-7-oxo-2H,3H,3aH,3bH,8H,9H,9bH,10H,11H-cyclopenta[a]phenanthren-1-yl]propanoyl\}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid 0
                    (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-[[(17R)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl]oxy]oxane-2-carboxylic acid 0
                    (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid 0
                    (3a,5b,7a,12a)-24-[(carboxymethyl)amino]-1,12-dihydroxy-24-oxocholan-3-yl-b-D-Glucopyranosiduronic acid 0
                    11-Oxo-androsterone glucuronide 0
                    11-beta-Hydroxyandrosterone-3-glucuronide 0
                    11alpha-hydroxyprogesterone 11-glucosiduronic acid 0
                    16-epiestriol 16-O-(beta-D-glucuronide) 0
                    16-epiestriol 3-O-(beta-D-glucuronide) 0
                    16alpha-hydroxyestrone 16-O-(beta-D-glucuronide) 0
                    16alpha-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                    17-alpha-Estradiol-3-glucuronide 0
                    17-beta-Estradiol-3-glucuronide 0
                    17-epiestriol 16-O-(beta-D-glucuronide) 0
                    17-epiestriol 17-O-(beta-D-glucuronide) 0
                    17-epiestriol 3-O-(beta-D-glucuronide) 0
                    17-hydroxyandrostane-3-glucuronide 0
                    17alpha-(N-Acetyl-D-glucosaminyl)-estradiol 3-D-glucuronide 0
                    17alpha-(N-acetyl-D-glucosaminyl)estradiol 3-glucosiduronic acid 0
                    17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucuronoside 0
                    17alpha-estradiol 17-O-(beta-D-glucuronide) 0
                    17alpha-estradiol 3-glucosiduronic acid 0
                    17beta-Estradiol-3-(beta-D-glucuronide) 17-sulfate 0
                    17beta-estradiol 17-glucosiduronic acid 23
                    17beta-estradiol 3-glucosiduronic acid 2
                    17beta-estradiol 3-sulfate 17-(beta-D-glucosiduronic acid) 0
                    1alpha-methyl-5alpha-androstan-3alpha-ol-17-one glucuronide 0
                    2-hydroxy-17beta-estradiol 2-O-(beta-D-glucuronide) 0
                    2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                    2-hydroxyestrone 2-O-(beta-D-glucuronide) 0
                    2-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                    2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                    2-methoxyestrone 3-O-(beta-D-glucuronide) 0
                    3-alpha,20-alpha-dihydroxy-5-beta-pregnane 3-glucuronide 0
                    3-alpha-Androstanediol glucuronide 0
                    3-alpha-hydroxy-5-alpha-androstane-17-one 3-D-glucuronide 0
                    3alpha-hydroxy-5alpha-androstane-17-one 3-D-glucuronide 0
                    3alpha-hydroxy-5beta-androstan-17-one 3-glucosiduronic acid 0
                    4-Hydroxyandrostenedione glucuronide 0
                    4-androsten-17beta-ol-3-one glucosiduronate 0
                    4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                    4-hydroxy-17beta-estradiol 4-O-(beta-D-glucuronide) 0
                    4-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                    4-hydroxyestrone 4-O-(beta-D-glucuronide) 0
                    4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                    4-methoxyestrone 3-O-(beta-D-glucuronide) 0
                    5-Ene-methyl-cholate-3-O-beta-D-glucuronopyranosyl-(14)-alpha-L- rhamnopyranoside 0
                    5alpha-androstane-3alpha,17beta-diol 17-glucosiduronic acid 0
                    5alpha-androstane-3beta,17beta-diol 17-O-(beta-D-glucuronide) 0
                    5alpha-androstane-3beta,17beta-diol 3-O-(beta-D-glucuronide) 0
                    5alpha-dihydrotestosterone 17-O-(beta-D-glucuronide) 0
                    5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronide] 0
                    6-dehydrotestosterone 17-glucosiduronic acid 0
                    Aldosterone 18-glucuronide 1
                    Cholest-5-en-3-yl beta-D-glucopyranosiduronic acid 0
                    Cholesterol glucuronide 0
                    Eryloside W 0
                    Estradiol acetate glucuronide 0
                    Glycochenodeoxycholic acid 3-glucuronide 0
                    Pandaroside A 0
                    Pandaroside B 0
                    Pregnanediol-3-glucuronide 0
                    Pregnanetriol 3a-O-b-D-glucuronide 0
                    Tetrahydroaldosterone-3-glucuronide 0
                    androsterone 3-glucosiduronic acid 1
                    bile alcohol glucuronide 0
                    calcidiol 25-O-(beta-D-glucuronide) 0
                    calcidiol 3-O-(beta-D-glucuronide) 0
                    calcitriol 25-O-(beta-D-glucuronide) 0
                    chenodeoxycholic acid 24-O-(beta-D-glucuronide) 0
                    chenodeoxycholic acid 3-O-(beta-D-glucuronide) 0
                    cholesterol beta-d-glucoside 0
                    cholic acid 24-O-(beta-D-glucuronide) 0
                    cholic acid glucuronide 0
                    dehydroisoandrosterone 3-glucuronide 0
                    deoxycholic acid 24-O-(beta-D-glucuronide) 0
                    deoxycholic acid 3-glucuronide 0
                    epitestosterone 17-O-(beta-D-glucuronide) 0
                    estriol 16-O-(beta-D-glucuronide) 1
                    estriol 3-O-(beta-D-glucuronide) 1
                    estrone 3-O-(beta-D-glucuronide) 1
                    etiocholanolone 3-glucuronide 0
                    hyocholic acid 24-O-(beta-D-glucuronide) 0
                    hyocholic acid 6-O-(beta-D-glucuronide) 0
                    hyodeoxycholic acid 24-O-(beta-D-glucuronide) 0
                    hyodeoxycholic acid 6-O-(beta-D-glucuronide) 0
                    lithocholic acid 24-O-(beta-D-glucuronide) 0
                    lithocholic acid 3-O-(beta-D-glucuronide) 0
                    testosterone 17-glucosiduronic acid 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbohydrates and carbohydrate derivatives 15270
                                    carbohydrate 15270
                                      carbohydrate derivative 14278
                                        glycosyl compound 13035
                                          glycoside 11818
                                            glycosiduronic acid 192
                                              glucosiduronic acid 192
                                                steroid glucosiduronic acid 25
                                                  (2S,3S,4R,5S,6R)-6-(\{3-[(1R,3aS,3bR,9aR,9bS,11aS)-1-hydroxy-9a,11a-dimethyl-7-oxo-2H,3H,3aH,3bH,8H,9H,9bH,10H,11H-cyclopenta[a]phenanthren-1-yl]propanoyl\}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid 0
                                                  (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-[[(17R)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl]oxy]oxane-2-carboxylic acid 0
                                                  (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid 0
                                                  (3a,5b,7a,12a)-24-[(carboxymethyl)amino]-1,12-dihydroxy-24-oxocholan-3-yl-b-D-Glucopyranosiduronic acid 0
                                                  11-Oxo-androsterone glucuronide 0
                                                  11-beta-Hydroxyandrosterone-3-glucuronide 0
                                                  11alpha-hydroxyprogesterone 11-glucosiduronic acid 0
                                                  16-epiestriol 16-O-(beta-D-glucuronide) 0
                                                  16-epiestriol 3-O-(beta-D-glucuronide) 0
                                                  16alpha-hydroxyestrone 16-O-(beta-D-glucuronide) 0
                                                  16alpha-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                                                  17-alpha-Estradiol-3-glucuronide 0
                                                  17-beta-Estradiol-3-glucuronide 0
                                                  17-epiestriol 16-O-(beta-D-glucuronide) 0
                                                  17-epiestriol 17-O-(beta-D-glucuronide) 0
                                                  17-epiestriol 3-O-(beta-D-glucuronide) 0
                                                  17-hydroxyandrostane-3-glucuronide 0
                                                  17alpha-(N-Acetyl-D-glucosaminyl)-estradiol 3-D-glucuronide 0
                                                  17alpha-(N-acetyl-D-glucosaminyl)estradiol 3-glucosiduronic acid 0
                                                  17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucuronoside 0
                                                  17alpha-estradiol 17-O-(beta-D-glucuronide) 0
                                                  17alpha-estradiol 3-glucosiduronic acid 0
                                                  17beta-Estradiol-3-(beta-D-glucuronide) 17-sulfate 0
                                                  17beta-estradiol 17-glucosiduronic acid 23
                                                  17beta-estradiol 3-glucosiduronic acid 2
                                                  17beta-estradiol 3-sulfate 17-(beta-D-glucosiduronic acid) 0
                                                  1alpha-methyl-5alpha-androstan-3alpha-ol-17-one glucuronide 0
                                                  2-hydroxy-17beta-estradiol 2-O-(beta-D-glucuronide) 0
                                                  2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                                                  2-hydroxyestrone 2-O-(beta-D-glucuronide) 0
                                                  2-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                                                  2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                                                  2-methoxyestrone 3-O-(beta-D-glucuronide) 0
                                                  3-alpha,20-alpha-dihydroxy-5-beta-pregnane 3-glucuronide 0
                                                  3-alpha-Androstanediol glucuronide 0
                                                  3-alpha-hydroxy-5-alpha-androstane-17-one 3-D-glucuronide 0
                                                  3alpha-hydroxy-5alpha-androstane-17-one 3-D-glucuronide 0
                                                  3alpha-hydroxy-5beta-androstan-17-one 3-glucosiduronic acid 0
                                                  4-Hydroxyandrostenedione glucuronide 0
                                                  4-androsten-17beta-ol-3-one glucosiduronate 0
                                                  4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                                                  4-hydroxy-17beta-estradiol 4-O-(beta-D-glucuronide) 0
                                                  4-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                                                  4-hydroxyestrone 4-O-(beta-D-glucuronide) 0
                                                  4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                                                  4-methoxyestrone 3-O-(beta-D-glucuronide) 0
                                                  5-Ene-methyl-cholate-3-O-beta-D-glucuronopyranosyl-(14)-alpha-L- rhamnopyranoside 0
                                                  5alpha-androstane-3alpha,17beta-diol 17-glucosiduronic acid 0
                                                  5alpha-androstane-3beta,17beta-diol 17-O-(beta-D-glucuronide) 0
                                                  5alpha-androstane-3beta,17beta-diol 3-O-(beta-D-glucuronide) 0
                                                  5alpha-dihydrotestosterone 17-O-(beta-D-glucuronide) 0
                                                  5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronide] 0
                                                  6-dehydrotestosterone 17-glucosiduronic acid 0
                                                  Aldosterone 18-glucuronide 1
                                                  Cholest-5-en-3-yl beta-D-glucopyranosiduronic acid 0
                                                  Cholesterol glucuronide 0
                                                  Eryloside W 0
                                                  Estradiol acetate glucuronide 0
                                                  Glycochenodeoxycholic acid 3-glucuronide 0
                                                  Pandaroside A 0
                                                  Pandaroside B 0
                                                  Pregnanediol-3-glucuronide 0
                                                  Pregnanetriol 3a-O-b-D-glucuronide 0
                                                  Tetrahydroaldosterone-3-glucuronide 0
                                                  androsterone 3-glucosiduronic acid 1
                                                  bile alcohol glucuronide 0
                                                  calcidiol 25-O-(beta-D-glucuronide) 0
                                                  calcidiol 3-O-(beta-D-glucuronide) 0
                                                  calcitriol 25-O-(beta-D-glucuronide) 0
                                                  chenodeoxycholic acid 24-O-(beta-D-glucuronide) 0
                                                  chenodeoxycholic acid 3-O-(beta-D-glucuronide) 0
                                                  cholesterol beta-d-glucoside 0
                                                  cholic acid 24-O-(beta-D-glucuronide) 0
                                                  cholic acid glucuronide 0
                                                  dehydroisoandrosterone 3-glucuronide 0
                                                  deoxycholic acid 24-O-(beta-D-glucuronide) 0
                                                  deoxycholic acid 3-glucuronide 0
                                                  epitestosterone 17-O-(beta-D-glucuronide) 0
                                                  estriol 16-O-(beta-D-glucuronide) 1
                                                  estriol 3-O-(beta-D-glucuronide) 1
                                                  estrone 3-O-(beta-D-glucuronide) 1
                                                  etiocholanolone 3-glucuronide 0
                                                  hyocholic acid 24-O-(beta-D-glucuronide) 0
                                                  hyocholic acid 6-O-(beta-D-glucuronide) 0
                                                  hyodeoxycholic acid 24-O-(beta-D-glucuronide) 0
                                                  hyodeoxycholic acid 6-O-(beta-D-glucuronide) 0
                                                  lithocholic acid 24-O-(beta-D-glucuronide) 0
                                                  lithocholic acid 3-O-(beta-D-glucuronide) 0
                                                  testosterone 17-glucosiduronic acid 1
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