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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
ISO |
arecaidine results in increased expression of TIMP1 mRNA; arecaidine results in increased expression of TIMP1 protein |
CTD |
PMID:16311067 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
[cassine co-treated with spectaline] results in decreased expression of CCND1 mRNA |
CTD |
PMID:26616281 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
[cassine co-treated with spectaline] results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:26616281 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
[cassine co-treated with spectaline] results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:26616281 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
CYP1A1 protein affects the metabolism of and results in increased activity of N'-nitrosoanabasine |
CTD |
PMID:11774366 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp2a1 |
cytochrome P450, family 2, subfamily a, polypeptide 1 |
multiple interactions decreases activity |
ISO |
N'-nitrosoanabasine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone] N'-nitrosoanabasine results in decreased activity of CYP2A13 protein |
CTD |
PMID:27567546 |
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NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
CYP3A4 protein affects the metabolism of and results in increased activity of N'-nitrosoanabasine |
CTD |
PMID:11774366 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Ugt1a5 |
UDP glucuronosyltransferase family 1 member A5 |
increases glucuronidation |
ISO |
UGT1A4 protein results in increased glucuronidation of N'-nitrosoanabasine |
CTD |
PMID:18238858 |
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NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Cyp2a1 |
cytochrome P450, family 2, subfamily a, polypeptide 1 |
increases activity |
ISO |
CYP2A13 protein results in increased activity of N-nitrosoguvacoline |
CTD |
PMID:15725615 |
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NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases chemical synthesis |
ISO |
CYP2B6 protein results in increased chemical synthesis of nicotine imine |
CTD |
PMID:30906561 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Casp3 |
caspase 3 |
increases activity |
ISO |
pancratistatin results in increased activity of CASP3 protein |
CTD |
PMID:15726366 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
[voacamine co-treated with Paclitaxel] results in increased cleavage of PARP1 protein |
CTD |
PMID:34856211 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects localization multiple interactions |
ISO |
voacamine affects the localization of RELA protein Paclitaxel promotes the reaction [voacamine affects the localization of RELA protein] |
CTD |
PMID:34856211 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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