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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-methoxy-TEMPO
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Accession:CHEBI:180670 term browser browse the term
Definition:A member of the class of aminoxyls that is TEMPO carrying a methoxy substituent at position 4.
Synonyms:exact_synonym: (4-methoxy-2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl
 related_synonym: 2,2,6,6-Tetramethyl-4-methoxypiperidine-1-oxyl;   2,2,6,6-tetramethyl-4-methoxypiperidine 1-oxide;   2,2,6,6-tetramethylpiperidine-4-methoxy-1-oxyl;   4-Methoxy-2,2,6,6-tetramethylpiperidinyloxyl;   4-methoxy-2,2,6,6-tetramethyl-1-piperidinyloxy;   4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxy;   4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxyl;   4-methoxy-2,2,6,6-tetramethylpiperidine 1-oxide;   4-methoxy-2,2,6,6-tetramethylpiperidine-1-oxy;   4-methoxy-2,2,6,6-tetramethylpiperidine-N-oxyl;   4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy;   4-methoxy-2,2,6,6-tetramethylpiperidinyloxy;   4-methoxy-TEMPO free radical;   Formula=C10H20NO2;   InChI=1S/C10H20NO2/c1-9(2)6-8(13-5)7-10(3,4)11(9)12/h8H,6-7H2,1-5H3;   InChIKey=SFXHWRCRQNGVLJ-UHFFFAOYSA-N;   MeO-TEMPO;   Metexyl;   SMILES=COC1CC(C)(C)N([O])C(C)(C)C1
 xref: CAS:95407-69-5;   Chemspider:8488900
 xref_mesh: MESH:C062073
 xref: PMID:10697546;   PMID:18728872;   PMID:18972469;   PMID:2610866;   PMID:27001507;   PMID:28688768;   PMID:28993908;   PMID:30878645;   PMID:31142008;   PMID:31593888;   PMID:31638966;   PMID:33382248;   Reaxys:4740399


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4-methoxy-TEMPO term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chek1 checkpoint kinase 1 increases phosphorylation ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of CHEK1 protein CTD PMID:28993908 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of CHEK2 protein CTD PMID:28993908 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions		 ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein
Acetylcysteine inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein]; pyrazolanthrone inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein]		 CTD PMID:28993908 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases metabolic processing ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased metabolism of MAP1LC3B protein CTD PMID:28993908 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO U 0126 inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of MAPK1 protein] CTD PMID:28993908 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of MAPK3 protein
U 0126 inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of MAPK3 protein]		 CTD PMID:28993908 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in decreased expression of SQSTM1 protein CTD PMID:28993908 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          autophagy inducer 2009
            4-methoxy-TEMPO 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organic heteromonocyclic compound 17773
                                    piperidines 7737
                                      TEMPO 102
                                        4-methoxy-TEMPO 7
paths to the root