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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:coniferol
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Accession:CHEBI:17745 term browser browse the term
Definition:A phenylpropanoid that is one of the main monolignols, produced by the reduction of the carboxy functional group in cinnamic acid and the addition of a hydroxy and a methoxy substituent to the aromatic ring.
Synonyms:exact_synonym: 4-[(1E)-3-hydroxyprop-1-en-1-yl]-2-methoxyphenol
 related_synonym: (E)-coniferol;   4-(3-hydroxy-1-propenyl)-2-methoxyphenol;   4-[(1E)-3-hydroxy-1-propenyl]-2-methoxyphenol;   Coniferyl alcohol;   Formula=C10H12O3;   InChI=1S/C10H12O3/c1-13-10-7-8(3-2-6-11)4-5-9(10)12/h2-5,7,11-12H,6H2,1H3/b3-2+;   InChIKey=JMFRWRFFLBVWSI-NSCUHMNNSA-N;   SMILES=C1=C(C(=CC=C1/C=C/CO)O)OC;   trans-coniferol;   trans-coniferyl alcohol
 alt_id: CHEBI:14016;   CHEBI:14017;   CHEBI:23371;   CHEBI:3858;   CHEBI:4730
 xref: Beilstein:2048963;   CAS:458-35-5;   FooDB:FDB015496;   HMDB:HMDB0012915;   KEGG:C00590;   KNApSAcK:C00000614;   MetaCyc:CONIFERYL-ALCOHOL;   PDBeChem:N7I;   PMID:11430982;   PMID:11684179;   PMID:12676987;   PMID:20336005;   PMID:21319787;   PMID:22851762;   PMID:22920542;   PMID:23131896;   PMID:23159486;   PMID:23188459;   PMID:23448127;   PMID:23624856;   PMID:23633600;   PMID:23876147;   PMID:31629237;   PMID:6660881;   Reaxys:2048963;   Wikipedia:Coniferyl_alcohol


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(+)-pinoresinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions
decreases expression		 ISO [loliolide co-treated with pinoresinol] results in decreased expression of ACACA protein
pinoresinol results in decreased expression of ACACA protein		 CTD PMID:31610126 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases expression		 ISO [loliolide co-treated with pinoresinol] results in decreased expression of FASN protein
pinoresinol results in decreased expression of FASN protein		 CTD PMID:31610126 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO pinoresinol results in increased ubiquitination of and results in increased degradation of and results in decreased expression of NR1H2 protein CTD PMID:31610126 NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO pinoresinol results in increased ubiquitination of and results in increased degradation of and results in decreased expression of NR1H3 protein CTD PMID:31610126 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO pinoresinol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:21191767 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
multiple interactions		 ISO pinoresinol results in decreased expression of SREBF1 protein
[loliolide co-treated with pinoresinol] results in decreased expression of SREBF1 protein		 CTD PMID:31610126 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO pinoresinol results in decreased secretion of TNF protein CTD PMID:29740324 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          volatile oil component 7613
            coniferol 7
              buddlenol B 0
              coniferin 0
              coniferyl acetate 0
              coniferyl benzoate 0
              coniferyl ester + 0
              coniferyl p-coumarate 0
              dehydrodiconiferyl alcohol + 0
              glycosmisic acid + 0
              guaiacyl lignin + 0
              guaiacylglycerol beta-coniferyl ether 0
              pinoresinol + 7
              simulanol 0
              trans-coniferyl alcohol diacetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                carbocyclic compound 18559
                                  benzenoid aromatic compound 17968
                                    benzenes 17830
                                      methoxybenzenes 2049
                                        monomethoxybenzene 1852
                                          guaiacols 1387
                                            coniferol 7
                                              buddlenol B 0
                                              coniferin 0
                                              coniferyl acetate 0
                                              coniferyl benzoate 0
                                              coniferyl ester + 0
                                              coniferyl p-coumarate 0
                                              dehydrodiconiferyl alcohol + 0
                                              glycosmisic acid + 0
                                              guaiacyl lignin + 0
                                              guaiacylglycerol beta-coniferyl ether 0
                                              pinoresinol + 7
                                              simulanol 0
                                              trans-coniferyl alcohol diacetate 0
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