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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:actin polymerisation inducer
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Accession:CHEBI:176495 term browser browse the term
Definition:Any substance that induces the polymerisation of the protein actin.
Synonyms:related_synonym: actin polymerisation enhancer;   actin polymerisation enhancers;   actin polymerisation inducers;   inducer of actin polymerization;   inducers of actin polymerization
 xref: PMID:33066873


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jaspamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle increases expression ISO
EXP		 jasplakinolide results in increased expression of ACTA2 protein
jasplakinolide results in increased expression of ACTA2 mRNA		 CTD PMID:11035001 PMID:23517783 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Actg1 actin, gamma 1 multiple interactions ISO jasplakinolide inhibits the reaction [UPF1 protein binds to ACTG1 protein]; jasplakinolide inhibits the reaction [UPF2 protein binds to ACTG1 protein]; jasplakinolide inhibits the reaction [UPF3B protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232 		JBrowse link
G Ahnak AHNAK nucleoprotein multiple interactions ISO jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [AHNAK protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [AHNAK protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr 1:205,882,225...205,970,934
Ensembl chr 1:205,882,273...205,970,926 		JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
increases expression		 ISO jasplakinolide results in increased expression of and results in increased secretion of CCN1 protein; YAP1 protein affects the reaction [jasplakinolide results in increased expression of CCN1 protein]
jasplakinolide results in increased expression of CCN1 mRNA		 CTD PMID:24040060 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
multiple interactions		 ISO jasplakinolide results in increased expression of CCN2 mRNA
jasplakinolide results in increased expression of and results in increased secretion of CCN2 protein; YAP1 protein affects the reaction [jasplakinolide results in increased expression of CCN2 protein]		 CTD PMID:24040060 PMID:25690654 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Cdh1 cadherin 1 decreases expression
multiple interactions		 ISO jasplakinolide results in decreased expression of CDH1 protein
jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH1 protein]		 CTD PMID:20388789 PMID:25756282 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH2 protein] CTD PMID:20388789 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdh5 cadherin 5 multiple interactions ISO jasplakinolide inhibits the reaction [Ethanol results in increased uptake of CDH5 protein] CTD PMID:22331491 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368 		JBrowse link
G Ctnna1 catenin alpha 1 multiple interactions EXP jasplakinolide affects the reaction [CTNNA1 protein affects the susceptibility to Cisplatin] CTD PMID:27989596 NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910 		JBrowse link
G Diaph1 diaphanous-related formin 1 affects localization ISO jasplakinolide affects the localization of DIAPH1 protein CTD PMID:22918941 NCBI chr18:29,669,659...29,769,070
Ensembl chr18:29,669,659...29,769,172 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions		 ISO jasplakinolide results in increased expression of GDF15 mRNA; jasplakinolide results in increased expression of GDF15 protein
[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [jasplakinolide results in increased expression of GDF15 protein]		 CTD PMID:23996089 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO jasplakinolide affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO jasplakinolide inhibits the reaction [TNF protein affects the localization of ICAM1 protein] CTD PMID:15034928 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions ISO jasplakinolide promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 jasplakinolide promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
jasplakinolide inhibits the reaction [latrunculin B promotes the reaction [IL1B protein results in increased expression of NOS2 protein]]		 CTD PMID:11502570 PMID:12799187 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mrtfa myocardin related transcription factor A affects localization ISO jasplakinolide affects the localization of MRTFA protein CTD PMID:23517783 NCBI chr 7:112,544,305...112,714,418
Ensembl chr 7:112,544,312...112,714,418 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 jasplakinolide promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
jasplakinolide inhibits the reaction [latrunculin B promotes the reaction [IL1B protein results in increased expression of NOS2 protein]]		 CTD PMID:11502570 PMID:12799187 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G P2rx1 purinergic receptor P2X 1 multiple interactions
affects localization		 ISO jasplakinolide inhibits the reaction [Cholesterol deficiency results in decreased activity of P2RX1 protein]
jasplakinolide affects the localization of P2RX1 protein		 CTD PMID:21757694 NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623 		JBrowse link
G Rs1 retinoschisin 1 decreases secretion ISO jasplakinolide results in decreased secretion of RS1 protein CTD PMID:21738583 NCBI chr  X:33,962,440...33,992,203
Ensembl chr  X:33,963,657...33,992,115 		JBrowse link
G S100a1 S100 calcium binding protein A1 multiple interactions ISO jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544 		JBrowse link
G Septin9 septin 9 multiple interactions ISO jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr10:102,409,798...102,579,056
Ensembl chr10:102,409,711...102,579,055 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO jasplakinolide inhibits the reaction [AHNAK protein affects the localization of SNAI1 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the localization of SNAI1 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the localization of SNAI1 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO jasplakinolide results in decreased expression of SPP1 protein CTD PMID:19026636 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Srf serum response factor increases activity ISO jasplakinolide results in increased activity of SRF protein CTD PMID:11502570 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733 		JBrowse link
G Tagln transgelin increases expression ISO
EXP		 jasplakinolide results in increased expression of TAGLN protein
jasplakinolide results in increased expression of TAGLN mRNA		 CTD PMID:11035001 PMID:15184395 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO jasplakinolide inhibits the reaction [TNF protein affects the localization of ICAM1 protein]; jasplakinolide inhibits the reaction [TNF protein affects the localization of VCAM1 protein]; jasplakinolide promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 PMID:15034928 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Upf1 UPF1, RNA helicase and ATPase affects localization
multiple interactions		 ISO jasplakinolide affects the localization of UPF1 protein
jasplakinolide inhibits the reaction [UPF1 protein binds to ACTG1 protein]		 CTD PMID:28743738 NCBI chr16:19,076,594...19,097,365
Ensembl chr16:19,076,322...19,096,568 		JBrowse link
G Upf2 UPF2, regulator of nonsense mediated mRNA decay multiple interactions ISO jasplakinolide inhibits the reaction [UPF2 protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr17:72,224,575...72,335,896
Ensembl chr17:72,225,316...72,335,855 		JBrowse link
G Upf3b UPF3B, regulator of nonsense mediated mRNA decay multiple interactions
affects localization		 ISO jasplakinolide inhibits the reaction [UPF3B protein binds to ACTG1 protein]
jasplakinolide affects the localization of UPF3B protein		 CTD PMID:28743738 NCBI chr  X:116,335,308...116,353,332
Ensembl chr  X:116,335,308...116,353,236 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO jasplakinolide inhibits the reaction [TNF protein affects the localization of VCAM1 protein] CTD PMID:15034928 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vim vimentin multiple interactions ISO jasplakinolide inhibits the reaction [AHNAK protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of VIM protein] CTD PMID:20388789 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions ISO jasplakinolide results in decreased phosphorylation of and affects the localization of YAP1 protein; YAP1 protein affects the reaction [jasplakinolide results in increased expression of CCN1 protein]; YAP1 protein affects the reaction [jasplakinolide results in increased expression of CCN2 protein] CTD PMID:24040060 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
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  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          actin polymerisation inducer 33
            jaspamide 33
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