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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:naphthalene-1,2-diol
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Accession:CHEBI:17435 term browser browse the term
Definition:A naphthalenediol that has formula C10H8O2.
Synonyms:related_synonym: 1,2-Dihydroxynaphthalene;   1,2-Naphthalenediol;   1,2-naphthohydroquinone;   Formula=C10H8O2;   InChI=1S/C10H8O2/c11-9-6-5-7-3-1-2-4-8(7)10(9)12/h1-6,11-12H;   InChIKey=NXPPAOGUKPJVDI-UHFFFAOYSA-N;   SMILES=Oc1ccc2ccccc2c1O;   beta-Naphthohydroquinone
 alt_id: CHEBI:14639;   CHEBI:18895;   CHEBI:49554;   CHEBI:7473
 xref: Beilstein:1908498;   CAS:574-00-5;   DrugBank:DB07610;   Gmelin:241000;   KEGG:C03012
 xref_mesh: MESH:C050642
 xref: UM-BBD_compID:c0129


show annotations for term's descendants           Sort by:
naphthalene-1,2-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [1,2-dihydroxynaphthalene analog results in increased activity of NFE2L2 protein] CTD PMID:25807370 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO 1,2-dihydroxynaphthalene analog results in increased expression of GCLC mRNA CTD PMID:25807370 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 1,2-dihydroxynaphthalene analog results in increased expression of HMOX1 mRNA; 1,2-dihydroxynaphthalene analog results in increased expression of HMOX1 protein CTD PMID:25807370 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases metabolic processing
multiple interactions		 ISO 1,2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein
Glutathione inhibits the reaction [1,2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein]		 CTD PMID:25807370 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases activity		 ISO Buthionine Sulfoximine promotes the reaction [1,2-dihydroxynaphthalene analog results in increased activity of NFE2L2 protein]; CAT protein inhibits the reaction [1,2-dihydroxynaphthalene analog results in increased activity of NFE2L2 protein] CTD PMID:25807370 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO 1,2-dihydroxynaphthalene analog results in increased expression of SLC7A11 mRNA; 1,2-dihydroxynaphthalene analog results in increased expression of SLC7A11 protein CTD PMID:25807370 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Top2a DNA topoisomerase II alpha affects activity ISO 1,2-dihydroxynaphthalene affects the activity of TOP2A protein CTD PMID:33760604 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Top2b DNA topoisomerase II beta affects activity ISO 1,2-dihydroxynaphthalene affects the activity of TOP2B protein CTD PMID:33760604 NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085 		JBrowse link
1,2-dihydronaphthalene-1,2-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephx1 epoxide hydrolase 1 multiple interactions ISO [EPHX1 protein results in increased metabolism of naphthalene] which results in increased chemical synthesis of 1,2-dihydroxy-1,2-dihydronaphthalene CTD PMID:18363382 PMID:26840748 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          metabolite 19484
            eukaryotic metabolite 19307
              animal metabolite 19174
                mammalian metabolite 19173
                  mouse metabolite 18871
                    naphthalene-1,2-diol 9
                      1,2-dihydronaphthalene-1,2-diol + 1
                      1,2-dihydroxynaphthalene-6-sulfonate 0
                      6-amino-1,2-dihydroxynaphthalene 0
                      8-methylnaphthalene-1,2-diol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                carbocyclic compound 18559
                                  carbopolycyclic compound 17167
                                    carbobicyclic compound 5872
                                      naphthalenes 3837
                                        hydroxynaphthalene 258
                                          naphthalenediols 14
                                            naphthalenediol 10
                                              naphthalene-1,2-diol 9
                                                1,2-dihydronaphthalene-1,2-diol + 1
                                                1,2-dihydroxynaphthalene-6-sulfonate 0
                                                6-amino-1,2-dihydroxynaphthalene 0
                                                8-methylnaphthalene-1,2-diol 0
paths to the root