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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pexidartinib
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Accession:CHEBI:145373 term browser browse the term
Definition:A pyrrolopyridine that is 5-chloro-1H-pyrrolo[2,3-b]pyridine which is substituted by a [6-({[6-(trifluoromethyl)pyridin-3-yl]methyl}amino)pyridin-3-yl]methyl group at position 3. It is a potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, KIT, and FLT3 (IC50 of 20 nM, 10 nM and 160 nM, respectively). Approved by the FDA for the treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT).
Synonyms:exact_synonym: 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine
 related_synonym: CML-261;   Formula=C20H15ClF3N5;   InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29);   InChIKey=JGWRKYUXBBNENE-UHFFFAOYSA-N;   PLX-3397;   PLX3397;   SMILES=C1=C(C=C2C(=N1)NC=C2CC3=CN=C(C=C3)NCC4=CC=C(N=C4)C(F)(F)F)Cl;   Turalio;   pexidartinibum
 xref: CAS:1029044-16-3;   DrugBank:DB12978;   KEGG:D11270
 xref_mesh: MESH:C000600259
 xref: PDBeChem:P31;   PMCID:PMC6012252;   PMID:26222558;   PMID:26449250;   PMID:30002809;   PMID:30628737;   PMID:30825104;   PMID:30926949;   PMID:31167689;   PMID:31213500;   PMID:31229240;   PMID:31240240;   PMID:31258629;   PMID:31602563;   PMID:31696640;   Wikipedia:Pexidartinib


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pexidartinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf1 colony stimulating factor 1 decreases secretion ISO pexidartinib results in decreased secretion of CSF1 protein CTD PMID:36368339 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Csf1r colony stimulating factor 1 receptor decreases activity ISO pexidartinib results in decreased activity of CSF1R protein CTD PMID:36368339 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases activity ISO pexidartinib results in decreased activity of FLT3 protein CTD PMID:36368339 NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases activity ISO pexidartinib results in decreased activity of KIT protein CTD PMID:36368339 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
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  CHEBI ontology 19808
    role 19784
      application 19627
        pharmaceutical 19468
          drug 19468
            antineoplastic agent 17749
              pexidartinib 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  azane 17798
                                    ammonia 17797
                                      organic amino compound 17797
                                        aromatic amine 15400
                                          aminopyridine 509
                                            pexidartinib 4
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