CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 3-oxo-Delta(4)-steroid group
Accession: CHEBI:136849
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Definition: An organic group derived from any 3-oxo-Delta(4)-steroid.
Synonyms: related_synonym: Formula=C6H6O; SMILES=C1=C(C*)*C(CC1=O)*; a 3-oxo-Delta4-steroid group
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AGT
angiotensinogen
increases abundance
EXP
AGT results in increased abundance of Aldosterone
CTD
PMID:2831029
NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
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POMC
proopiomelanocortin
increases abundance
EXP
POMC protein results in increased abundance of Aldosterone
CTD
PMID:2831029
NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
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CRH
corticotropin releasing hormone
increases abundance
EXP
CRH protein results in increased abundance of Hydrocortisone
CTD
PMID:2831029
NCBI chr29:15,831,944...15,840,560
Ensembl chr29:15,831,944...15,834,384
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INS
insulin
affects abundance multiple interactions
EXP
INS protein affects the abundance of Hydrocortisone Sodium affects the reaction [INS protein affects the abundance of Hydrocortisone]
CTD
PMID:1324617
NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
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POMC
proopiomelanocortin
increases abundance
EXP
POMC protein results in increased abundance of Hydrocortisone
CTD
PMID:2831029
NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
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AVP
arginine vasopressin
decreases expression
EXP
Dexamethasone results in decreased expression of AVP protein
CTD
PMID:1934541
NCBI chr24:18,183,057...18,184,827
Ensembl chr24:18,183,057...18,184,883
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HSD11B1
hydroxysteroid 11-beta dehydrogenase 1
increases expression
EXP
Dexamethasone results in increased expression of HSD11B1 mRNA
CTD
PMID:21798686
NCBI chr 7:8,344,380...8,409,901
Ensembl chr 7:8,344,447...8,409,897
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NPPA
natriuretic peptide A
increases expression
EXP
Dexamethasone results in increased expression of NPPA protein
CTD
PMID:1934541
NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
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AR
androgen receptor
multiple interactions
EXP
Eplerenone binds to and results in decreased activity of AR protein
CTD
PMID:23242577
NCBI chr24:34,713,390...34,731,461 NCBI chr X:51,969,785...52,167,450
Ensembl chr X:51,969,785...52,151,912
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ESR1
estrogen receptor 1
affects expression
EXP
Progesterone affects the expression of ESR1 protein
CTD
PMID:16483645
NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544
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PGR
progesterone receptor
affects binding
EXP
Progesterone binds to PGR protein
CTD
PMID:16054490
NCBI chr21:447,197...552,511
Ensembl chr21:447,319...552,511
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BAX
BCL2 associated X, apoptosis regulator
decreases expression
EXP
Spironolactone results in decreased expression of BAX protein
CTD
PMID:20082611
NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
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BCL2
BCL2 apoptosis regulator
increases expression
EXP
Spironolactone results in increased expression of BCL2 protein
CTD
PMID:20082611
NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
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CAPN1
calpain 1
decreases expression
EXP
Spironolactone results in decreased expression of CAPN1 protein
CTD
PMID:20082611
NCBI chr18:51,983,266...52,010,831
Ensembl chr18:51,983,824...52,010,757
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CASP3
caspase 3
decreases expression
EXP
Spironolactone results in decreased expression of CASP3 protein
CTD
PMID:20082611
NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
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CAST
calpastatin
increases expression
EXP
Spironolactone results in increased expression of CAST protein
CTD
PMID:20082611
NCBI chr 3:12,920,514...13,031,974
Ensembl chr 3:12,922,453...13,031,959
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MMP9
matrix metallopeptidase 9
decreases expression
EXP
Spironolactone results in decreased expression of MMP9 protein
CTD
PMID:20082611
NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293
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TIMP1
TIMP metallopeptidase inhibitor 1
increases expression
EXP
Spironolactone results in increased expression of TIMP1 protein
CTD
PMID:20082611
NCBI chr X:41,201,623...41,205,314
Ensembl chr X:41,201,638...41,205,310
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B9D2
B9 domain containing 2
increases expression
EXP
Testosterone results in increased expression of TGFB1 mRNA
CTD
PMID:17157324
NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885
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KCND3
potassium voltage-gated channel subfamily D member 3
increases expression
EXP
Testosterone results in increased expression of KCND3 protein
CTD
PMID:17054656
NCBI chr17:63,470,829...63,668,354
Ensembl chr17:63,470,415...63,668,035
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KCNJ2
potassium inwardly rectifying channel subfamily J member 2
increases expression
EXP
Testosterone results in increased expression of KCNJ2 protein
CTD
PMID:17054656
NCBI chr 9:16,468,938...16,475,722
Ensembl chr 9:16,468,938...16,475,722
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