PGR (progesterone receptor) - Rat Genome Database

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Pathways
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Gene: PGR (progesterone receptor) Canis lupus familiaris
Analyze
Symbol: PGR
Name: progesterone receptor
RGD ID: 12122857
Description: ENCODES a protein that exhibits ATPase binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); enzyme binding (ortholog); INVOLVED IN cellular response to estrogen stimulus (ortholog); cellular response to follicle-stimulating hormone stimulus (ortholog); cellular response to gonadotropin stimulus (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Animal Mammary Neoplasms (ortholog); ataxia telangiectasia (ortholog); FOUND IN nucleus; axon (ortholog); axon terminus (ortholog); INTERACTS WITH progesterone
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: nuclear receptor subfamily 3 group C member 3; PR
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.121447,197 - 552,511 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl21447,319 - 552,511 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha21461,376 - 566,187 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.021609,104 - 717,242 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl21609,104 - 742,638 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.121392,996 - 497,928 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.021478,480 - 583,792 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.021532,736 - 637,643 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
progesterone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to estrogen stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to gonadotropin stimulus  (ISO)
cellular response to luteinizing hormone stimulus  (ISO)
cellular response to wortmannin  (ISO)
diterpenoid metabolic process  (ISO)
epithelial cell maturation  (IEA,ISO)
estrous cycle  (ISO)
female mating behavior  (ISO)
glandular epithelial cell maturation  (IEA,ISO)
intracellular steroid hormone receptor signaling pathway  (IBA,IEA)
lung alveolus development  (IEA,ISO)
luteinization  (ISO)
maintenance of protein location in nucleus  (ISO)
mammary gland development  (IEA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of granulosa cell apoptotic process  (ISO)
negative regulation of phosphorylation  (ISO)
ovulation from ovarian follicle  (IEA,ISO)
paracrine signaling  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
progesterone receptor signaling pathway  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of epithelial cell proliferation  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to cocaine  (ISO)
response to estrogen  (ISO)
response to progesterone  (ISO)
smooth muscle relaxation of the bladder outlet  (ISO)
steroid hormone mediated signaling pathway  (IEA)
tertiary branching involved in mammary gland duct morphogenesis  (IEA,ISO)

Cellular Component
axon  (ISO)
axon terminus  (ISO)
cytoplasm  (IEA)
dendrite  (ISO)
dendritic spine  (ISO)
nucleus  (IDA,IEA)
perikaryon  (ISO)
plasma membrane  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:11282275   PMID:16054892   PMID:19754547   PMID:19754577   PMID:20178635   PMID:22301074   PMID:25158022  


Genomics

Comparative Map Data
PGR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.121447,197 - 552,511 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl21447,319 - 552,511 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha21461,376 - 566,187 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.021609,104 - 717,242 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl21609,104 - 742,638 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.121392,996 - 497,928 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.021478,480 - 583,792 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.021532,736 - 637,643 (+)NCBIUU_Cfam_GSD_1.0
PGR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811101,029,624 - 101,129,813 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11101,029,624 - 101,129,813 (-)EnsemblGRCh38hg38GRCh38
GRCh3711100,900,355 - 101,000,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611100,414,313 - 100,506,465 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411100,414,312 - 100,506,465NCBI
Celera1198,069,715 - 98,169,894 (-)NCBICelera
Cytogenetic Map11q22.1NCBI
HuRef1196,837,449 - 96,937,628 (-)NCBIHuRef
CHM1_111100,783,609 - 100,883,736 (-)NCBICHM1_1
T2T-CHM13v2.011101,039,187 - 101,139,328 (-)NCBIT2T-CHM13v2.0
Pgr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3998,890,017 - 8,968,612 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl98,899,834 - 8,968,612 (+)EnsemblGRCm39 Ensembl
GRCm3898,898,900 - 8,968,611 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl98,899,833 - 8,968,611 (+)EnsemblGRCm38mm10GRCm38
MGSCv3798,899,833 - 8,968,611 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3698,862,303 - 8,926,995 (+)NCBIMGSCv36mm8
Celera96,279,529 - 6,348,253 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Pgr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8814,354,398 - 14,413,271 (+)NCBIGRCr8
mRatBN7.286,072,673 - 6,131,552 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl86,072,673 - 6,131,344 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx810,003,167 - 10,062,099 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.088,300,792 - 8,359,726 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.086,329,892 - 6,388,768 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.087,128,656 - 7,187,796 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl87,128,656 - 7,187,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.087,113,895 - 7,172,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.485,784,717 - 5,845,901 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.185,784,716 - 5,845,901 (+)NCBI
Celera87,609,728 - 7,668,047 (+)NCBICelera
Cytogenetic Map8q11NCBI
Pgr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554124,643,839 - 4,693,478 (-)NCBIChiLan1.0ChiLan1.0
PGR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29101,848,679 - 101,939,634 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111102,925,904 - 103,028,120 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01195,997,677 - 96,098,866 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11199,508,571 - 99,598,020 (-)NCBIpanpan1.1PanPan1.1panPan2
Pgr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494784,948,508 - 85,038,416 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365516,498,553 - 6,573,222 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365516,498,553 - 6,573,212 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PGR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl932,035,684 - 32,129,221 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1932,035,684 - 32,129,776 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2936,044,789 - 36,138,540 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9p13-p11NCBI
PGR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1192,420,970 - 92,519,128 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl192,430,453 - 92,517,296 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604333,353,079 - 33,447,583 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pgr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248781,714,559 - 1,762,421 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248781,714,196 - 1,769,302 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PGR
655 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 10 4 8 5
Below cutoff 5 4 12 6 5 6 6 2 8 5 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000006379   ⟹   ENSCAFP00000005906
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl21447,319 - 552,511 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845028059   ⟹   ENSCAFP00845022074
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl21609,104 - 742,638 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845028099   ⟹   ENSCAFP00845022110
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl21609,104 - 714,055 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845028128   ⟹   ENSCAFP00845022131
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl21609,104 - 714,055 (+)Ensembl
RefSeq Acc Id: NM_001003074   ⟹   NP_001003074
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.121447,197 - 552,511 (+)NCBI
Dog10K_Boxer_Tasha21461,376 - 566,187 (+)NCBI
ROS_Cfam_1.021609,104 - 714,055 (+)NCBI
UMICH_Zoey_3.121392,996 - 497,928 (+)NCBI
UNSW_CanFamBas_1.021478,480 - 583,792 (+)NCBI
UU_Cfam_GSD_1.021532,736 - 637,643 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038429442   ⟹   XP_038285370
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.021609,739 - 717,242 (+)NCBI
RefSeq Acc Id: XM_038429443   ⟹   XP_038285371
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.021611,460 - 717,242 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001003074   ⟸   NM_001003074
- UniProtKB: Q9GLW0 (UniProtKB/Swiss-Prot),   A0A8C0KED9 (UniProtKB/TrEMBL),   A0A8I3P6B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000005906   ⟸   ENSCAFT00000006379
RefSeq Acc Id: XP_038285370   ⟸   XM_038429442
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038285371   ⟸   XM_038429443
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845022074   ⟸   ENSCAFT00845028059
RefSeq Acc Id: ENSCAFP00845022131   ⟸   ENSCAFT00845028128
RefSeq Acc Id: ENSCAFP00845022110   ⟸   ENSCAFT00845028099
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003978 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030021409 UniProtKB/TrEMBL
  ENSCAFG00040012330 UniProtKB/TrEMBL
  ENSCAFG00805011335 UniProtKB/Swiss-Prot
  ENSCAFG00845015739 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006379.5 UniProtKB/Swiss-Prot
  ENSCAFT00000098658.1 UniProtKB/TrEMBL
  ENSCAFT00000109394.1 UniProtKB/TrEMBL
  ENSCAFT00030039446.1 UniProtKB/TrEMBL
  ENSCAFT00030039482.1 UniProtKB/TrEMBL
  ENSCAFT00030039542.1 UniProtKB/TrEMBL
  ENSCAFT00030039579.1 UniProtKB/TrEMBL
  ENSCAFT00030039662.1 UniProtKB/TrEMBL
  ENSCAFT00040022781.1 UniProtKB/TrEMBL
  ENSCAFT00040022925.1 UniProtKB/TrEMBL
  ENSCAFT00805020907 UniProtKB/Swiss-Prot
  ENSCAFT00845028059.1 UniProtKB/TrEMBL
  ENSCAFT00845028099 ENTREZGENE
  ENSCAFT00845028099.1 UniProtKB/TrEMBL
  ENSCAFT00845028128.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Progest_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403621 UniProtKB/Swiss-Prot
NCBI Gene PGR ENTREZGENE
PANTHER KNIRPS-RELATED PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROGESTERONE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prog_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PROGESTRONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0KED9 ENTREZGENE
  A0A8C0P410_CANLF UniProtKB/TrEMBL
  A0A8C0P7T0_CANLF UniProtKB/TrEMBL
  A0A8C0PC22_CANLF UniProtKB/TrEMBL
  A0A8C0PCC0_CANLF UniProtKB/TrEMBL
  A0A8C0PFS0_CANLF UniProtKB/TrEMBL
  A0A8C0SDD5_CANLF UniProtKB/TrEMBL
  A0A8C0SF24_CANLF UniProtKB/TrEMBL
  A0A8I3NXH2_CANLF UniProtKB/TrEMBL
  A0A8I3NY69_CANLF UniProtKB/TrEMBL
  A0A8I3P6B0 ENTREZGENE, UniProtKB/TrEMBL
  PRGR_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A8P0PKU8 UniProtKB/TrEMBL
  A0A8P0PLH3 UniProtKB/TrEMBL
VGNC ID VGNC:44469 ENTREZGENE