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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:BAY 60-6583
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Accession:CHEBI:131358 term browser browse the term
Definition:A member of the class of cyanopyridines that is 6-amino-3,5-dicyano-4-(4-hydroxyphenyl)-2-sulfanylpyridine in which the hydroxy and sulfanyl hydrogens are replaced by cyclopropylmethyl and carboxamidomethyl groups respectively.
Synonyms:exact_synonym: 2-({6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl}sulfanyl)acetamide
 related_synonym: Formula=C19H17N5O2S;   InChI=1S/C19H17N5O2S/c20-7-14-17(12-3-5-13(6-4-12)26-9-11-1-2-11)15(8-21)19(24-18(14)23)27-10-16(22)25/h3-6,11H,1-2,9-10H2,(H2,22,25)(H2,23,24);   InChIKey=ZTYHZMAZUWOXNC-UHFFFAOYSA-N;   SMILES=C=1(C(=C(N=C(C1C#N)N)SCC(=O)N)C#N)C2=CC=C(C=C2)OCC3CC3
 xref: CAS:910487-58-0
 xref_mesh: MESH:C518875
 xref: PMID:24633424;   PMID:25704806;   PMID:25728851;   PMID:26161239;   PMID:26447087;   Reaxys:15017054;   Wikipedia:BAY_60-6583


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BAY 60-6583 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor multiple interactions
increases expression		 EXP
ISO		 BAY 60-6583 binds to and results in increased activity of ADORA2B protein
BAY 60-6583 results in increased expression of ADORA2B mRNA; BAY 60-6583 results in increased expression of ADORA2B protein
BAY 60-6583 promotes the reaction [Ethanol results in increased expression of ADORA2B mRNA]; BAY 60-6583 promotes the reaction [Ethanol results in increased expression of ADORA2B protein]		 CTD PMID:19749167 PMID:35143882 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions
increases expression		 ISO 1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [[BAY 60-6583 co-treated with cobaltous chloride] results in increased expression of CXCL12 protein]; 1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [BAY 60-6583 results in increased expression of CXCL12 protein]; [BAY 60-6583 co-treated with cobaltous chloride] results in increased expression of CXCL12 protein CTD PMID:27590504 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression		 ISO 1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [BAY 60-6583 results in increased expression of FGF2 protein]; [BAY 60-6583 co-treated with cobaltous chloride] results in increased expression of FGF2 protein CTD PMID:27590504 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO BAY 60-6583 inhibits the reaction [Ethanol results in increased activity of GPT protein] CTD PMID:35143882 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions		 ISO BAY 60-6583 results in decreased expression of IL1B mRNA
BAY 60-6583 inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; BAY 60-6583 inhibits the reaction [Ethanol results in increased expression of IL1B protein]		 CTD PMID:35143882 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO BAY 60-6583 inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; BAY 60-6583 inhibits the reaction [Ethanol results in increased expression of IL6 protein]
BAY 60-6583 results in decreased expression of IL6 protein		 CTD PMID:35143882 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO BAY 60-6583 results in increased phosphorylation of MAPK1 protein CTD PMID:27590504 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO BAY 60-6583 results in increased phosphorylation of MAPK3 protein CTD PMID:27590504 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO BAY 60-6583 inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; BAY 60-6583 inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:35143882 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        anti-inflammatory agent 16580
          BAY 60-6583 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              monocarboxylic acid amide 15662
                                                BAY 60-6583 9
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