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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sulfisoxazole
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Accession:CHEBI:102484 term browser browse the term
Definition:A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.
Synonyms:exact_synonym: 4-amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide
 related_synonym: 3,4-Dimethyl-5-sulfanilamidoisoxazole;   3,4-Dimethyl-5-sulfonamidoisoxazole;   3,4-Dimethyl-5-sulphanilamidoisoxazole;   3,4-Dimethyl-5-sulphonamidoisoxazole;   3,4-Dimethylisoxazole-5-sulfanilamide;   3,4-Dimethylisoxazole-5-sulphanilamide;   4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide;   4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulphonamide;   5-(4-Aminophenylsulfonamido)-3,4-dimethylisoxazole;   5-(p-Aminobenzenesulfonamido)-3,4-dimethylisoxazole;   5-(p-Aminobenzenesulphonamido)-3,4-dimethylisoxazole;   5-Sulfanilamido-3,4-dimethylisoxazole;   5-Sulphanilamido-3,4-dimethyl-isoxazole;   Formula=C11H13N3O3S;   InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3;   InChIKey=NHUHCSRWZMLRLA-UHFFFAOYSA-N;   N'-(3,4)Dimethylisoxazol-5-yl-sulphanilamide;   N(1)-(3,4-dimethyl-5-isoxazolyl)sulfanilamide;   N(1)-(3,4-dimethyl-5-isoxazolyl)sulphanilamide;   SMILES=Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C;   Sulfadimethylisoxazole;   Sulfafurazol;   Sulfaisoxazole;   Sulfasoxazole;   Sulfisonazole;   Sulfisoxasole;   Sulfisoxazol;   Sulfofurazole;   Sulphadimethylisoxazole;   Sulphafurazol;   Sulphafurazole;   Sulphaisoxazole;   Sulphisoxazol;   Sulphofurazole;   sulfafurazole;   sulfafurazolum
 alt_id: CHEBI:9343
 xref: Beilstein:263871;   CAS:127-69-5;   DrugBank:DB00263;   Drug_Central:2529;   Gmelin:864477;   KEGG:C07318;   KEGG:D00450;   LINCS:LSM-3120
 xref_mesh: MESH:D013444
 xref: PMID:1861917;   PMID:4960234;   PMID:7356572;   Patent:US2430094;   Wikipedia:Sulfisoxazole


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sulfisoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO Sulfisoxazole inhibits the reaction [Bilirubin binds to ALB protein] CTD PMID:21280114 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO Sulfisoxazole results in increased expression of CYP3A4 mRNA
Sulfisoxazole results in increased expression of and results in increased activity of CYP3A4 protein		 CTD PMID:18505790 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfisoxazole decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Sulfisoxazole results in decreased activity of PON1 protein CTD PMID:28665493 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Sulfisoxazole results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    role 19820
      biological role 19818
        antimicrobial agent 18191
          sulfonamide antibiotic 2925
            sulfisoxazole 5
              sulfisoxazole diolamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    main group molecular entity 19792
                      s-block molecular entity 19626
                        hydrogen molecular entity 19613
                          hydrides 19115
                            inorganic hydride 18121
                              pnictogen hydride 18110
                                nitrogen hydride 18017
                                  azane 17823
                                    ammonia 17797
                                      organic amino compound 17822
                                        aromatic amine 15425
                                          anilines 14425
                                            substituted aniline 14066
                                              sulfanilamide 2920
                                                sulfisoxazole 5
                                                  sulfisoxazole diolamine 0
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