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Strain: CDF, Fischer CDF

Source

Fischer (CDF), F344/DuCrl: Charles River

Physical Features


Coat color	White (albino)
Behavior	Normal
Other distinguishing features	n/a

Growth/Development

Body weight

	8 weeks	10 weeks	13 weeks
Male	157 ± 4 g	211 ± 3 g	235 ± 5 g
Female	119 ± 2 g	141 ± 2 g	148 ± 2 g

Reproduction

Average litter size	see Charles River
Average generation time	see Charles River
Fertility	N/A

Phenotype Data

Clinical Measurement

left ventricular diastolic blood pressure

left ventricular systolic blood pressure

mean arterial blood pressure

body temperature

left ventricular developed pressure

red blood cell count

blood hemoglobin level

blood neutrophil count

blood lymphocyte count

blood monocyte count

blood eosinophil count

mean corpuscular volume

blood glucose level

plasma anion gap

heart wet weight

heart weight to body weight ratio

lung dry weight to body weight ratio

heart right ventricle weight to left ventricle weight ratio

plasma renin activity level

minute ventilation (VE)

arterial blood flow rate

partial pressure of blood carbon dioxide (Pco2)

percent change in ventilation

respiration rate

mean corpuscular hemoglobin level

mean corpuscular hemoglobin concentration

absolute change in partial pressure of blood carbon dioxide

absolute change in partial pressure of blood oxygen

absolute change in blood pH

blood insulin level

blood glucose level area under curve (AUC)

change in blood insulin level

serum total cholesterol level

total white blood cell count

total serum bilirubin level

partial pressure of blood oxygen (Po2)

serum bicarbonate level

serum chloride level

serum potassium level

serum sodium level

serum calcium level

percent change in respiration rate

percent change in tidal volume

absolute change in mean arterial blood pressure

absolute change in heart rate

plasma creatinine level

serum phosphate level

serum glucose level

serum albumin level

serum alanine aminotransferase activity level

serum alkaline phosphatase activity level

serum aspartate aminotransferase activity level

serum urea nitrogen level

absolute change in plasma renin activity level

serum total protein level

time to onset of heart contraction

time to peak heart contraction

heart contraction pressure

heart left ventricle infarction weight to total heart left ventricle weight ratio

absolute change in body temperature

calculated pulmonary vascular resistance normalized to body weight

FAPGG metabolism-surface area product

methylene blue metabolism-surface area product without auto-oxidation

methylene blue metabolism-surface area product after auto-oxidation

methylene blue to FAPGG metabolism-surface area product ratio

dose of methacholine at which pulmonary conductance is half its pretreatment value (ED50)

fractional change in blood vessel diameter per unit change in intravascular pressure

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)

logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)

concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

maximum contractile force per wet weight of aorta

acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction

sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constriction

hypoxia-induced blood vessel dilation expressed as percent of force at maximum constriction

percent change in heart rate

percent change in arterial blood flow rate

percent change in left ventricular developed pressure

percent change in left ventricular systolic blood pressure

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

creatinine clearance

heart effluent lactate dehydrogenase activity level normalized to heart weight

serum globulin level

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