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Pathways

Tlr1, 2, 6 ligands

Tlr1 is mostly complexed with tlr2 to recognize try-acylated lipopeptides whereas Tlr2 heterodimer with Tlr6 recognizes di-acylated lipopeptides. In addition, a variety of ligands for Tlr2 have been found. For more information check PMID: 21235323, 19840864. The particular ligands for Tlr1, 2 and 6 are listed and if available, links are provided:

Tlr1 – try-acylated lipopeptides
Tlr2 – peptidoglycan, lipoteichoic acid, lipomannans, zymosan
Tlr6 – di-acylated lipopeptides


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.