Kcn channels

The voltage-gated potassium channel alpha-subunit comprises 11 families and several related families in mammals. Kcn acts as an antagonist of glucose-mediated insulin secretion and this effect appears to be in turn antagonized by components of the pathway. The alpha subunit identified as mediating the voltage-dependent outward potassium current in the mammalian beta cells is Kcnb1 (known as Kv2.1), the first member of family 2, also known as Shab. Three regulatory beta subunits have been identified; they are related to the NADPH-dependent oxidoreductase enzymes and are thought to confer redox sensitivity upon the channel. The three genes are expressed in the beta cells of human and rat but their association with Kcnb1 remains to be established. More information can be found in PMID 12830383. Only Kcnb1 is listed with aliases in parentheses, full name and link to the gene report page:

Kcnb1 (Kv2.1, Kcr1-1, Shab) – potassium voltage-gated channel subfamily B member 1