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Pathways

Kindlins

The kindlin family of proteins with FERM domains, like the talin proteins, bind to the cytoplasmic tail of the beta integrin receptors and regulate their function. The mammalian family consists of three members and their official names are fermitin family homolog 1, 2 and 3, respectively. For details on talins and kindlins in integrin receptor activation, check PMID 23860236. The three genes are listed with aliases in parentheses, full names and links to gene report pages:

Fermt1 (kindlin1, UNC-112 related protein 1) – fermitin family member 1
Fermt2 (kindlin2, Plekhc1) – fermitin family member 2
Fermt3 (kindlin3, KIND3) – fermitin family member 3


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.