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Strain Registration

Strain: SS.BN-(D12Arb13-D12Rat79)/Mcwi

Symbol: SS.BN-(D12Arb13-D12Rat79)/Mcwi
Strain: SS.BN-(D12Arb13-D12Rat79)
Substrain: Mcwi
RGD ID: 629510
Citation ID: RRID:RGD_629510
Ontology ID: RS:0000813
Also Known As: SS.BN-(D12Arb13-D12Rat79)/Mcwi
Type: congenic
Available Source: Not Available
Origination: PhysGen
Description: A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed
Coat Color: albino
Last Known Status: Live Animals
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21859,796,478 - 59,796,643RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0182,745,212 - 61,985,812RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.0182,761,846 - 61,177,004RGD_MAPPER_PIPELINERnor_5.0
RGSC_v3.4182,848,113 - 62,229,060RGD_MAPPER_PIPELINERGSC_v3.4





Disease Annotations     Click to see Annotation Detail View
Albuminuria  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
body temperature
left ventricular developed pressure
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
plasma anion gap
heart wet weight
heart weight to body weight ratio
lung dry weight to body weight ratio
heart right ventricle weight to left ventricle weight ratio
plasma renin activity level
minute ventilation
arterial blood flow rate
tidal volume
partial pressure of blood carbon dioxide (Pco2)
percent change in ventilation
respiration rate
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in blood pH
serum total cholesterol level
total white blood cell count
serum total bilirubin level
blood pH
partial pressure of blood oxygen
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
percent change in respiration rate
percent change in tidal volume
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum phosphate level
serum glucose level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
serum total protein level
time to onset of heart contraction
time to peak heart contraction
heart contraction pressure
heart left ventricle infarction weight to total heart left ventricle weight ratio
absolute change in body temperature
calculated pulmonary vascular resistance normalized to body weight
FAPGG metabolism-surface area product
methylene blue metabolism-surface area product without auto-oxidation
methylene blue metabolism-surface area product after auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value
fractional change in blood vessel diameter per unit change in intravascular pressure
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
percent change in heart rate
percent change in arterial blood flow rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
urine total protein excretion rate
urine albumin excretion rate
urine sodium excretion rate
urine potassium excretion rate
creatinine clearance
heart effluent lactate dehydrogenase activity level normalized to heart weight
serum globulin level

References

References - curated
# Reference Title Reference Citation
1. Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease. Mattson DL, etal., Am J Physiol Renal Physiol. 2008 Sep;295(3):F837-42. Epub 2008 Jul 23.
2. PhysGen Strains PhysGen strains
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D18Chm31)
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,745,212 - 2,745,433NCBI
Rnor_5.0182,761,846 - 2,762,067UniSTS
RGSC_v3.4182,848,113 - 2,848,334UniSTS
Celera182,389,333 - 2,389,554UniSTS
Cytogenetic Map18 RGD

Flank 2 / 1 (D18Mit8)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21859,796,478 - 59,796,643 (+)MAPPER
Rnor_6.01861,985,648 - 61,985,812NCBI
Rnor_5.01861,176,840 - 61,177,004UniSTS
RGSC_v3.41862,228,896 - 62,229,060UniSTS
Celera1857,917,062 - 57,917,198UniSTS
RGSC_v3.11862,301,978 - 62,302,324RGD
RH 3.4 Map18604.6RGD
RH 3.4 Map18604.6UniSTS
RH 2.0 Map18307.7RGD
SHRSP x BN Map1832.1699RGD
Cytogenetic Map18q12.1UniSTS

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease The blood pressure of females is 130 mmHg and of males is 123 mmHg. 629526
strain_other The average weight of females is 195g and of males 299g. 629526
strain_reproduction The average litter size is 7.9 pups and the average generation time is 41 days. 629526

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-12 SS.BN-(D12Arb13-D12Rat79)/Mcwi    SS.BN-(D12Arb13-D12Rat79)/Mcwi    Name updated 68913 APPROVED
2013-08-12 SS.BN-(D12Arb13-D12Rat79)/Mcwi    SS.BN-(D12Arb13-D12Rat79)/Mcwi    Name updated 68913 APPROVED