| 126925136 | SD-Mstnem1Cqin | | ZFN constructs were designed to target the genomic region of rat Mstn exon 1. A ZFN construct engineered to target bp 277 to 281 of rat Mstn was used for the rat embryo injection. The # 6 founder was found to have sequence changed from GATCA to AGTC, resulting in a frame shift mutation within the open reading frame and generate an early termination codon, resulting in a truncated 109 amino acid peptide (wild type is 376). ZFN mutant founders were backcrossed to Spargue Dawley rats to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. | | mutant | 2 | symbol , origin , old_strain_symbol |
| 5143985 | SS-Mstnem1Mcwi | | This strain was produced by injecting ZFNs targeting the sequence CTTATTCCTTTGCAGCTGActttctAATGCAAGCGGATGGA into SS/JrHsdMcwi rat embryos. The resulting mutation deletes part of exon 2 and its splice acceptor. | | mutant | 1 | symbol , old_strain_symbol |
| 5131954 | SS-Mstnem2Mcwi | | This strain was produced by injecting ZFNs targeting the sequence CTTATTCCTTTGCAGCTGActttctAATGCAAGCGGATGGA into SS/JrHsdMcwi rat embryos. The resulting mutation is an 18-bp frameshift deletion in exon 2. | | mutant | 1 | symbol , old_strain_symbol |
| 5131964 | SS-Mstnem3Mcwi | | This strain was produced by injecting ZFNs targeting the sequence CTTATTCCTTTGCAGCTGActttctAATGCAAGCGGATGGA into SS/JrHsdMcwi rat embryos. The resulting mutation is an 8-bp frameshift deletion in exon 2. | | mutant | 1 | symbol , old_strain_symbol |
| 5686715 | SS-Mstnem1Mcwi+/+ | SS-Mstnem1Mcwi+/Mstnem1Mcwi+ | ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. | | mutant | 1 | symbol , name , old_strain_symbol |
| 5686713 | SS-Mstnem1Mcwi-/- | SS-Mstnem1Mcwi-/Mstnem1Mcwi- | ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. | | mutant | 4 | symbol , name , old_strain_symbol |
| 5686721 | SS-Mstnem3Mcwi+/+ | SS-Mstnem3Mcwi+/Mstnem3Mcwi+ | ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. | | mutant | 1 | symbol , name , old_strain_symbol |
| 5686723 | SS-Mstnem3Mcwi-/+ | SS-Mstnem3Mcwi-/Mstnem3Mcwi+ | ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. | | mutant | 1 | symbol , name , old_strain_symbol |
| 5686718 | SS-Mstnem3Mcwi-/- | SS-Mstnem3Mcwi-/Mstnem3Mcwi- | ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. | | mutant | 1 | symbol , old_strain_name , name , old_strain_symbol |