Zfp445 (zinc finger protein 445) - Rat Genome Database

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Gene: Zfp445 (zinc finger protein 445) Rattus norvegicus
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Symbol: Zfp445
Name: zinc finger protein 445
RGD ID: 1559144
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding activity; and double-stranded DNA binding activity. Predicted to be involved in epigenetic programing of female pronucleus; negative regulation of gene expression via chromosomal CpG island methylation; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF445 (zinc finger protein 445); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; chloroprene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC301076; RGD1559144; sim to ZFP; similar to ZFP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88131,331,795 - 131,350,749 (-)NCBIGRCr8
mRatBN7.28122,453,175 - 122,473,355 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8122,454,328 - 122,473,286 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8128,048,569 - 128,067,523 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08126,247,510 - 126,266,464 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08124,073,249 - 124,092,180 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08131,885,119 - 131,904,303 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8131,888,047 - 131,899,023 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08131,040,161 - 131,059,338 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48127,543,965 - 127,562,919 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8121,572,120 - 121,591,074 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23376485   PMID:30602440  


Genomics

Comparative Map Data
Zfp445
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88131,331,795 - 131,350,749 (-)NCBIGRCr8
mRatBN7.28122,453,175 - 122,473,355 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8122,454,328 - 122,473,286 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8128,048,569 - 128,067,523 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08126,247,510 - 126,266,464 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08124,073,249 - 124,092,180 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08131,885,119 - 131,904,303 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8131,888,047 - 131,899,023 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08131,040,161 - 131,059,338 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48127,543,965 - 127,562,919 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8121,572,120 - 121,591,074 (-)NCBICelera
Cytogenetic Map8q32NCBI
ZNF445
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38344,431,705 - 44,477,670 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl344,431,705 - 44,477,670 (-)EnsemblGRCh38hg38GRCh38
GRCh37344,473,197 - 44,519,162 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36344,456,266 - 44,494,166 (-)NCBINCBI36Build 36hg18NCBI36
Build 34344,457,427 - 44,494,166NCBI
Celera344,419,283 - 44,457,181 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef344,525,629 - 44,563,411 (-)NCBIHuRef
CHM1_1344,431,370 - 44,469,269 (-)NCBICHM1_1
T2T-CHM13v2.0344,447,545 - 44,493,482 (-)NCBIT2T-CHM13v2.0
Zfp445
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399122,677,988 - 122,715,916 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9122,673,594 - 122,695,071 (-)EnsemblGRCm39 Ensembl
GRCm389122,848,910 - 122,886,851 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9122,844,529 - 122,866,006 (-)EnsemblGRCm38mm10GRCm38
MGSCv379122,758,028 - 122,775,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369122,699,716 - 122,714,649 (-)NCBIMGSCv36mm8
Celera9123,298,383 - 123,315,513 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map973.18NCBI
Znf445
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542026,986,101 - 26,991,678 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542026,972,008 - 26,995,063 (+)NCBIChiLan1.0ChiLan1.0
ZNF445
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2244,384,465 - 44,424,763 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1344,383,474 - 44,429,531 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0344,327,299 - 44,367,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1345,389,465 - 45,425,416 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl345,389,465 - 45,425,416 (-)Ensemblpanpan1.1panPan2
ZNF445
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1231,906,958 - 1,940,340 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl231,927,625 - 1,939,382 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha231,940,000 - 1,973,057 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0232,151,269 - 2,184,377 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl232,152,078 - 2,184,347 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1231,992,031 - 2,025,014 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0232,116,578 - 2,149,414 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0232,086,857 - 2,117,687 (+)NCBIUU_Cfam_GSD_1.0
Znf445
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118198,714,344 - 198,734,956 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366951,066,703 - 1,087,289 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF445
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1327,748,438 - 27,783,325 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11327,748,437 - 27,783,348 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21330,586,137 - 30,621,025 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF445
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1225,914,639 - 5,951,506 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl225,919,544 - 5,928,452 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041161,223,240 - 161,260,222 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf445
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473075,928,735 - 75,952,261 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473075,927,861 - 75,952,155 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp445
67 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:787
Count of miRNA genes:326
Interacting mature miRNAs:425
Transcripts:ENSRNOT00000034690
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
RH132319  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28122,454,455 - 122,454,638 (+)MAPPERmRatBN7.2
Rnor_6.08131,885,247 - 131,885,429NCBIRnor6.0
Rnor_5.08131,040,289 - 131,040,471UniSTSRnor5.0
RGSC_v3.48127,544,093 - 127,544,275UniSTSRGSC3.4
Celera8121,572,248 - 121,572,430UniSTS
RH 3.4 Map81261.1UniSTS
Cytogenetic Map8q32UniSTS
RH143629  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28122,454,481 - 122,454,676 (+)MAPPERmRatBN7.2
Rnor_6.08131,885,273 - 131,885,467NCBIRnor6.0
Rnor_5.08131,040,315 - 131,040,509UniSTSRnor5.0
RGSC_v3.48127,544,119 - 127,544,313UniSTSRGSC3.4
Celera8121,572,274 - 121,572,468UniSTS
RH 3.4 Map81256.9UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000034690   ⟹   ENSRNOP00000036378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8122,454,328 - 122,473,286 (-)Ensembl
Rnor_6.0 Ensembl8131,888,047 - 131,899,023 (-)Ensembl
RefSeq Acc Id: NM_001191802   ⟹   NP_001178731
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88131,331,795 - 131,350,749 (-)NCBI
mRatBN7.28122,454,328 - 122,473,283 (-)NCBI
Rnor_6.08131,885,119 - 131,904,290 (-)NCBI
Rnor_5.08131,040,161 - 131,059,338 (-)NCBI
Celera8121,572,120 - 121,591,074 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178731 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL76790 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036378.5
RefSeq Acc Id: NP_001178731   ⟸   NM_001191802
- UniProtKB: D3ZAK3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000036378   ⟸   ENSRNOT00000034690
Protein Domains
C2H2-type   KRAB   SCAN box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAK3-F1-model_v2 AlphaFold D3ZAK3 1-977 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559144 AgrOrtholog
BioCyc Gene G2FUF-28636 BioCyc
Ensembl Genes ENSRNOG00000025554 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034690.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.4020.10 UniProtKB/TrEMBL
  6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Krueppel_C2H2_ZnF UniProtKB/TrEMBL
  SCAN_sf UniProtKB/TrEMBL
  Tscrpt_reg_SCAN UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene 301076 ENTREZGENE
PANTHER KRAB DOMAIN C2H2 ZINC FINGER UniProtKB/TrEMBL
  KRAB DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  KRAB DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  SCAN UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp445 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  SCAN_BOX UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025554 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  SCAN UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  Retrovirus capsid dimerization domain-like UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A6I487_RAT UniProtKB/TrEMBL
  D3ZAK3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Zfp445  zinc finger protein 445  RGD1559144_predicted  similar to ZFP (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559144_predicted  sim to ZFP (predicted)  LOC301076  sim to ZFP  Symbol and Name status set to approved 1299863 APPROVED
2005-12-28 LOC301076  sim to ZFP      Symbol and Name status set to provisional 70820 PROVISIONAL