Spata1 Reference Search Result - Rat Genome Database

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RGD ID	Title	Citation	Abstract	PubMed	Pub Date
11557175	Spata19 is critical for sperm mitochondrial function and male fertility.	Mi Y, etal., Mol Reprod Dev. 2015 Nov;82(11):907-13. doi: 10.1002/mrd.22536. Epub 2015 Aug 24.	Haploid round spermatids undergo differentiation and morphogenesis during spermiogenesis, resulting in mature spermatozoa. The molecular details underlying this transformation, however, remain poorly understood. In this study, we generated and analyzed germ cell-specific Spata1 ... (more) ;'>Spata19 knockout mice (Spata19(flox/flox) ; Stra8-Cre; hereafter termed "Spata19 cKO") to assess the model that SPATA19 contributes to mitochondrial function in differentiating spermatids. Spata19-cKO males were infertile, as their sperm exhibited disorganized mitochondrial structure; furthermore, their sperm-abundance of mitochondrial proteins, activities of mitochondrial respiratory chain complex IV, and ATP levels were significantly reduced. Yet, the infertility of Spata19-cKO males was rescued by intracytoplasmic sperm injection, so the sperm are capable of initiating development. Collectively, our findings suggest that SPATA19 plays an important role in sperm motility by regulating the organization and function of the mitochondria.	26265198	2015-11-01
598116825	Homozygous mutation in SPATA16 is associated with male infertility in human globozoospermia.	Dam AH, etal., Am J Hum Genet. 2007 Oct;81(4):813-20. doi: 10.1086/521314. Epub 2007 Aug 21.	Globozoospermia is a rare (incidence <0.1% in male infertile patients) form of teratozoospermia, mainly characterized by round-headed spermatozoa that lack an acrosome. It originates from a disturbed spermiogenesis, which is expected to be induced by a genetic factor. Several family cases and recess ... (more) ive mouse models with the same phenotype support this expectation. In this study, we present a consanguineous family with three affected brothers, in whom we have identified a homozygous mutation in the spermatogenesis-specific gene SPATA16. This is the first example of a nonsyndromic male infertility condition in humans caused by an autosomal gene defect, and it could also mean that the identification of other partners like SPATA16 could elucidate acrosome formation.	17847006	2007-10-01