S1pr3 Reference Search Result - Rat Genome Database

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RGD ID	Title	Citation	Abstract	PubMed	Pub Date
11079644	Corticotrophin-releasing factor participates in S1PR3-dependent cPLA2 expression and cell motility in vascular smooth muscle cells.	Zhu C, etal., Vascul Pharmacol. 2015 Aug;71:116-26. doi: 10.1016/j.vph.2015.03.013. Epub 2015 Apr 10.	This work is to investigate the role of CRF receptors in VSMC migration and the relevant mechanisms. We studied the role of CRF receptors in cell motility and found that S1P signaling pathway is involved in the regulation of cPLA2 induced by CRF. S1P is synthesized by Sphk1 and Sphk2 and binds to fi ... (more) ve GPCR designated S1P1-5. We observed that activation of CRFR1 resulted in increased cell migration, whereas activation of CRFR2 resulted in decreased cell migration. cPLA2 and iPLA2 were knocked down respectively to explore the corresponding effect on cell migration by means of shRNA interference. cPLA2 expression was increased by CRFR1 but decreased by CRFR2. On the contrary, iPLA2 expression was inhibited by CRFR1 but enhanced by CRFR2. The regulation of cPLA2 was in line with the regulation of Sphk1 and hence cell migration after the activation of CRFR1 or CRFR2. Consistently, S1P release was enhanced with CRFR1 activation. Both DMS (Sphk inhibitor) and CAY10444 (S1PR3 inhibitor) attenuated cPLA2 expression and thus decreased cell migration in response to CRF. In addition, CRF could not promote cell migration after S1PR3 silencing. Our results suggest the pro-migratory role of CRFR1-Sphk1-S1P-S1PR3-cPLA2 signaling pathway in VSMCs.	25869501	2015-05-01
11086246	The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination.	Muppidi JR, etal., J Exp Med. 2015 Dec 14;212(13):2213-22. doi: 10.1084/jem.20151250. Epub 2015 Nov 16.	The orphan Galpha13-coupled receptor P2RY8 is mutated in human germinal center (GC)-derived lymphomas and was recently found to promote B cell association with GCs in a mouse model. Here we establish that P2RY8 promotes clustering of activated B cells within follicles in a follicular dendritic cell ... (more) (FDC)-dependent manner. Although mice lack a P2RY8 orthologue, we show that mouse GC B cell clustering is also dependent on FDCs acting to support the function of a Galpha13-coupled receptor. Mutations in GNA13 and its downstream effector ARHGEF1 are associated with the development of disseminated GC-derived lymphomas. We find that egress of Gna13 mutant GC B cells from lymph nodes in the mouse depends on sphingosine-1-phosphate receptor-3. These findings provide evidence that FDCs promote GC confinement of both human and mouse GC B cells via Galpha13-dependent pathways, and they show that dissemination of Galpha13-deficient GC B cells additionally requires an egress-promoting receptor.	26573295	2015-06-01