| 11911529 | ERBB2 | erb-b2 receptor tyrosine kinase 2 | ENCODES a protein that exhibits Hsp90 protein binding (ortholog); protein tyrosine kinase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN axon regeneration (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to mechanical stimulus (orthol og); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; endometrial cancer pathway; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); amblyopia (ortholog); Animal Disease Models (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog) | 17 | 17560337 | 17600808 | Bonobo | 321 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11812560 | TOB1 | transducer of ERBB2, 1 | ENCODES a protein that exhibits receptor tyrosine kinase binding (inferred); SMAD binding (inferred); transcription corepressor activity (inferred); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of osteoblast differentiation (ortholog); regulation of SMAD p rotein signal transduction (ortholog); ASSOCIATED WITH Chloracne (ortholog); endometriosis (ortholog); Experimental Neoplasms (ortholog); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | 17 | 44953343 | 44957465 | Bonobo | 33 | name | gene, protein-coding, MODEL [RefSeq] |
| 11824507 | TOB2 | transducer of ERBB2, 2 | ENCODES a protein that exhibits nuclear vitamin D receptor binding (ortholog); INVOLVED IN negative regulation of osteoclast differentiation (ortholog); positive regulation of ossification (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH vitiligo (ortholog) | 22 | 22329783 | 22344795 | Bonobo | 10 | name | gene, protein-coding, MODEL [RefSeq] |
| 11747533 | ERBIN | erbb2 interacting protein | ENCODES a protein that exhibits protein kinase binding (inferred); signaling receptor binding (inferred); INVOLVED IN protein targeting (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); prostate cancer (ortholog); FOUND IN neuromuscular junction (ortholog); postsynaptic specialization (ortholog) | 5 | 47929305 | 48081381 | Bonobo | 51 | name | gene, protein-coding, MODEL [RefSeq] |
| 11669000 | CPNE3 | copine 3 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (inferred); calcium-dependent protein binding (inferred); metal ion binding (inferred); INVOLVED IN cellular response to calcium ion (inferred); cellular response to growth factor stimulus (inferred); ERBB2 ;'>ERBB2 signaling pathway (inferred); ASSOCIATED WITH Prostatic Neoplasms (ortholog); FOUND IN cell junction (inferred); cytoplasm (inferred); cytosol (inferred) | 8 | 83209949 | 83257088 | Bonobo | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 11955338 | EGF | epidermal growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PAR TICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN extracellular space (ortholog) | 4 | 102410724 | 102509691 | Bonobo | 155 | description | gene, protein-coding, MODEL [RefSeq] |
| 11962137 | EREG | epiregulin | ENCODES a protein that exhibits growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB2-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH cholesteatoma (ortholog); erythropoietic protoporphyria (ortholog); Experimental Colitis (ortholog); FOUND IN extracellular space (ortholog) | 4 | 49806505 | 49827961 | Bonobo | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 11981791 | MAP2K2 | mitogen-activated protein kinase kinase 2 | ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase kinase activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN epithelial cell proliferation involved in lung morphogenesis (ortholog); ERBB2-ERBB3 signaling pathway (ortholog); E RK1 and ERK2 cascade (ortholog); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; endothelin signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); breast cancer (ortholog); cardiofaciocutaneous syndrome (ortholog); FOUND IN cell cortex (ortholog); cytoplasm (ortholog) | 19 | 3114445 | 3148619 | Bonobo | 123 | description | gene, protein-coding, MODEL [RefSeq] |
| 11891171 | NRG2 | neuregulin 2 | ENCODES a protein that exhibits epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); ErbB-3 class receptor binding (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); epidermal growth factor receptor signaling pathway (ort holog); ERBB2-ERBB3 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog) | 5 | 135212496 | 135411469 | Bonobo | 39 | description | gene, protein-coding, MODEL [RefSeq] |
| 11826938 | TGFA | transforming growth factor alpha | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN angiogenesis (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PARTICIPATES IN altered epidermal gr owth factor/neuregulin signaling pathway; epidermal growth factor/neuregulin signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH acute kidney failure (ortholog); Animal Mammary Neoplasms (ortholog); Experimental Liver Neoplasms (ortholog); FOUND IN extracellular space (ortholog) | 2A | 70510727 | 70617628 | Bonobo | 84 | description | gene, protein-coding, MODEL [RefSeq] |