| 1550651 | Uba1 | ubiquitin-like modifier activating enzyme 1 | This gene encodes a member of the ubiquitin-activating E1 family. The encoded protein initiates the ubiquitin activation and transfer cascade, catalyzing the first step in ubiquitin conjugation to mark cellular proteins for proteasome degradation. Ubiquitin activating enzymes use ATP to form a thioe ster between a conserved catalytic cysteine of the enzyme and the C-terminal carboxylate of ubiquitin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] | X | 20524660 | 20549420 | Mouse | 193 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1323790 | Uba2 | ubiquitin-like modifier activating enzyme 2 | Enables SUMO activating enzyme activity. Predicted to be involved in positive regulation of protein sumoylation and protein sumoylation. Part of SUMO activating enzyme complex. Is expressed in several structures, including branchial arch; lens; limb; and neural fold. Orthologous to human UBA2 (ubiqu itin like modifier activating enzyme 2). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 33840121 | 33868014 | Mouse | 136 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 737107 | Uba1y | ubiquitin-activating enzyme, Chr Y | Enables ubiquitin activating enzyme activity. Predicted to be involved in DNA damage response; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. Is expressed in adrenal gland; brain; gonad; and liver. [provided by Alliance of Genome Resources, Jul 2025] | Y | 818612 | 843684 | Mouse | 34 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1623274 | Uba1y-ps1 | ubiquitin-activating enzyme, Chr Y, pseudogene 1 | | Y | 2637211 | 2649592 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1623273 | Uba1y-ps2 | ubiquitin-activating enzyme, Chr Y, pseudogene 2 | | Y | 2262021 | 2278688 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 15039140 | Uba1y-rs1 | ubiquitin-activating enzyme, Chr Y related sequence 1 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 15037907 | Uba1y-rs2 | ubiquitin-activating enzyme, Chr Y related sequence 2 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 15037697 | Uba1y-rs3 | ubiquitin-activating enzyme, Chr Y related sequence 3 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 15037510 | Uba1y-rs4 | ubiquitin-activating enzyme, Chr Y related sequence 4 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |