Predicted to enable nuclear thyroid hormone receptor binding activity and ubiquitin protein ligase activity. Involved in regulation of embryonic development. Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. Is expressed in several structures, including brain and genit
ourinary system. Human ortholog(s) of this gene implicated in Clark-Baraitser syndrome. Orthologous to human TRIP12 (thyroid hormone receptor interactor 12). [provided by Alliance of Genome Resources, Jul 2025]