Predicted to enable calcium channel activity and ribosome binding activity. Involved in calcium ion transmembrane transport; endoplasmic reticulum calcium ion homeostasis; and ossification. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of multi-pass translocon compl
ex. Predicted to be active in endoplasmic reticulum. Is expressed in clavicle; mandible; maxilla; and rib. Used to study craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome. Human ortholog(s) of this gene implicated in craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 1. Orthologous to human TMCO1 (transmembrane and coiled-coil domains 1). [provided by Alliance of Genome Resources, Jul 2025]
Involved in mitochondrial respirasome assembly. Located in mitochondrion. Is expressed in adrenal gland; gut; liver lobe; and submandibular gland primordium. Human ortholog(s) of this gene implicated in craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 2. O