| 11336 | Sparc | secreted acidic cysteine rich glycoprotein | Enables calcium ion binding activity and extracellular matrix binding activity. Acts upstream of or within several processes, including bone development; cellular response to growth factor stimulus; and pigmentation. Located in extracellular matrix and extracellular space. Is expressed in several st ructures, including brain; egg cylinder; genitourinary system; jaw; and sensory organ. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 55284985 | 55310906 | Mouse | 422 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736596 | Sparcl1 | SPARC-like 1 | Predicted to enable calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Involved in synaptic membrane adhesion. Is active in glutamatergic synapse. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mese nchyme; genitourinary system; and sensory organ. Orthologous to human SPARCL1 (SPARC like 1). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 104226974 | 104261954 | Mouse | 143 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1552814 | Smoc1 | SPARC related modular calcium binding 1 | Enables extracellular matrix binding activity. Involved in eye development and limb development. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in basement membrane. Is expressed in several structures, including alimentary sys tem; central nervous system; genitourinary system; hindlimb; and sensory organ. Used to study microphthalmia with limb anomalies. Human ortholog(s) of this gene implicated in microphthalmia with limb anomalies. Orthologous to human SMOC1 (SPARC related modular calcium binding 1). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 81073582 | 81233188 | Mouse | 245 | old_gene_name , name , description , ensembl_full_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1315437 | Smoc2 | SPARC related modular calcium binding 2 | Enables calcium ion binding activity and heparin binding activity. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in basement membrane and interstitial matrix. Is expressed in several structures, including alimentary system; c entral nervous system; genitourinary system; heart; and hemolymphoid system gland. Orthologous to human SMOC2 (SPARC related modular calcium binding 2). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 14499768 | 14625052 | Mouse | 207 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1322985 | Spock1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 | Predicted to enable several functions, including calcium ion binding activity; collagen binding activity; and endopeptidase inhibitor activity. Involved in central nervous system neuron differentiation and neuron migration. Located in neuromuscular junction; node of Ranvier; and sarcoplasm. Is activ e in postsynaptic density. Is expressed in several structures, including jaw; nervous system; sensory organ; skeletal musculature; and thymus primordium. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SPOCK1 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 57569008 | 58056194 | Mouse | 136 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1318417 | Spock2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 | Enables extracellular matrix binding activity and glycosaminoglycan binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor; extracellular matrix organization; and positive regulation of cell-substrate adhesion. Located in collagen-containing extracellular matrix . Is expressed in Sertoli cell; brain; and germ cell of testis. Orthologous to human SPOCK2 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2). [provided by Alliance of Genome Resources, Apr 2025] | 10 | 59942079 | 59971020 | Mouse | 94 | name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1313841 | Spock3 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3 | Enables glycosaminoglycan binding activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Is expressed in central nervous system and retina. Orthologous to human SPOCK3 (SPARC style='font-weight:700;'>SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 63404034 | 63810135 | Mouse | 83 | name , description | gene, protein-coding, VALIDATED [RefSeq] |