Predicted to enable fibroblast growth factor binding activity and identical protein binding activity. Acts upstream of or within several processes, including axonogenesis; microtubule depolymerization; and positive regulation of RNA splicing. Located in several cellular components, including COPI-co
ated vesicle; Cajal body; and growth cone. Is expressed in several structures, including central nervous system; early conceptus; eye; gonad; and hemolymphoid system gland. Used to study Werdnig-Hoffmann disease; intermediate spinal muscular atrophy; and juvenile spinal muscular atrophy. Human ortholog(s) of this gene implicated in Werdnig-Hoffmann disease; adult spinal muscular atrophy; intermediate spinal muscular atrophy; juvenile spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human SMN1 (survival of motor neuron 1, telomeric) and SMN2 (survival of motor neuron 2, centromeric). [provided by Alliance of Genome Resources, Jul 2025]
Predicted to enable 5'-3' DNA exonuclease activity; beta-lactamase activity; and damaged DNA binding activity. Acts upstream of or within nucleotide-excision repair. Predicted to be located in fibrillar center and nucleoplasm. Orthologous to human DCLRE1A (DNA cross-link repair 1A). [provided by All