Enables DNA binding activity and ubiquitin protein ligase activity. Involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Acts upstream of or within negative regulation of axon extension and positive regulation of DNA-templated transcription. Located in PML
body; axon; and cytoplasm. Is expressed in central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma and squamous cell carcinoma. Orthologous to human RNF6 (ring finger protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Enables translation factor activity, non-nucleic acid binding and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of filopodium assembly; positive regulation of long-term neuronal synaptic plasticity; and regulation of synapse organization. Acts upstre
am of or within lactation; positive regulation of epidermal growth factor-activated receptor activity; and sperm axoneme assembly. Located in several cellular components, including dendrite; perikaryon; and plasma membrane. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including limb; limb bud; nervous system; sensory organ; and skin. Orthologous to human NEURL1 (neuralized E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2025]