Enables chromatin binding activity and histone H2B C-terminal K residue ubiquitin ligase activity. Predicted to be involved in several processes, including positive regulation of transcription by RNA polymerase II; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predic
ted to be located in nucleolus and nucleoplasm. Predicted to be part of HULC complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human RNF20 (ring finger protein 20). [provided by Alliance of Genome Resources, Jul 2025]
Predicted to enable Hsp70 protein binding activity and transmembrane transporter binding activity. Predicted to be involved in several processes, including positive regulation of delayed rectifier potassium channel activity; regulation of cardiac muscle contraction; and regulation of heart looping.
Predicted to be active in perinuclear region of cytoplasm. Orthologous to human RNF207 (ring finger protein 207). [provided by Alliance of Genome Resources, Apr 2025]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein autoubiquitination. Predicted to be located in cytosol and nucleoplasm. Is expressed in nervous system and neural retina. Orthologous to human RNF208 (ring finger protein