Enables GTPase activator activity and small GTPase binding activity. Involved in positive regulation of GTPase activity. Predicted to be located in mitochondrion; nuclear body; and plasma membrane. Predicted to be active in Schaffer collateral - CA1 synapse and membrane. Used to study microphthalmia
. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALBP1 (ralA binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Predicted to enable SH3 domain binding activity. Predicted to be involved in endocytosis and endosomal transport. Predicted to be located in clathrin-coated pit; cytosol; and nucleoplasm. Predicted to be active in cytoplasm and plasma membrane. Is expressed in cranium; lung; nervous system; otic cap
sule; and thymus primordium. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human REPS1 (RALBP1 associated Eps domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Predicted to enable calcium ion binding activity. Predicted to be involved in endocytosis and endosomal transport. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human REPS2 (RALBP1 associated Eps domain containing 2). [provided by Allia