Oaz2 Gene Search Result

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

Genes search result for Mus musculus
(View Results for all Objects and Ontologies)

2 records found for search term Oaz2

Refine Term:

Assembly:

Chr

Sort By:

Export

RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1624081	Oaz2	ornithine decarboxylase antizyme 2	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Anti ... (more) zymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]	9	65583830	65597582	Mouse	96	symbol , PhenoGen , old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
2294619	Oaz2-ps	ornithine decarboxylase antizyme 2, pseudogene	INTERACTS WITH titanium dioxide; trovafloxacin	3	135230732	135232397	Mouse	2	symbol , PhenoGen	gene, pseudo, MODEL [RefSeq]