The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against
tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. [provided by RefSeq, Feb 2013]
Enables identical protein binding activity and protein dimerization activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of cytokine production; and regulation of defense response. Acts upstream of or within several processes,
including defense response to Gram-positive bacterium; positive regulation of macrophage cytokine production; and regulation of autophagy. Located in cytosol; extracellular region; and nucleus. Part of NLRP6 inflammasome complex. Is expressed in several structures, including alimentary system; brain; heart; hemolymphoid system gland; and urinary system. Orthologous to human PYCARD (PYD and CARD domain containing). [provided by Alliance of Genome Resources, Jul 2025]