nerve growth factor receptor (TNFR superfamily, member 16)
Enables death receptor activity; nerve growth factor binding activity; and small GTPase binding activity. Involved in several processes, including circadian regulation of gene expression; dorsal aorta development; and intracellular glucose homeostasis. Acts upstream of or within several processes, i
ncluding hair follicle morphogenesis; nervous system development; and regulation of signal transduction. Located in several cellular components, including cell surface; cell-cell junction; and postsynaptic density. Is active in neuromuscular junction. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease and depressive disorder. Orthologous to human NGFR (nerve growth factor receptor). [provided by Alliance of Genome Resources, Jul 2025]
11
95459644
95478524
Mouse
615
symbol , old_gene_name , PhenoGen , description , old_gene_symbol
Enables death receptor binding activity and molecular function inhibitor activity. Involved in negative regulation of protein ubiquitination. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Located in cytosol. Is expressed in several structures, including
genitourinary system; gut; liver; nervous system; and sensory organ. Orthologous to human BEX3 (brain expressed X-linked 3). [provided by Alliance of Genome Resources, Jul 2025]