Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin binding activity; and transcription coactivator activity. Acts upstream of or within several processes, including chordate embryonic development; embryonic brain development; and glial cell development.
Part of mediator complex. Is expressed in brain; tibialis anterior; and tongue. Human ortholog(s) of this gene implicated in FG syndrome; leiomyosarcoma; major depressive disorder; phobic disorder; and syndromic X-linked intellectual disorder Lujan-Fryns-type. Orthologous to human MED12 (mediator complex subunit 12). [provided by Alliance of Genome Resources, Jul 2025]
Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of mediator complex. Orthologous to human MED12L (mediator complex subunit 12L). [provided by Alli