Lmna Gene Search Result

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Genes search result for Mus musculus
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3 records found for search term Lmna

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
732791	Lmna	lamin A	This gene encodes a protein that is a member of the lamin family. Nuclear lamins, intermediate filament-like proteins, are the major components of the nuclear lamina, a protein meshwork associated with the inner nuclear membrane. This meshwork is thought to maintain the integrity of the nuclear enve ... (more) lope, participate in chromatin organization, and regulate gene transcription. Vertebrate lamins consist of two types, A and B. This protein is an A-type and is proposed to be developmentally regulated. In mouse deficiency of this gene is associated with muscular dystrophy. Mouse lines with different mutations in this gene serve as pathophysiological models for several human laminopathies. In humans, mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013]	3	88388455	88413842	Mouse	1091	symbol , PhenoGen	gene, protein-coding, REVIEWED [RefSeq]
1557587	Lmntd1	lamin tail domain containing 1	Acts upstream of or within cell population proliferation. Located in cytoplasm and nuclear envelope. Orthologous to human LMNTD1 (lamin tail domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]	6	145311619	145560045	Mouse	37	old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
1618346	Mlip	muscular LMNA-interacting protein	Enables lamin binding activity and transcription corepressor activity. Involved in negative regulation of cardiac muscle hypertrophy in response to stress. Acts upstream of or within negative regulation of cardiac muscle hypertrophy and negative regulation of transcription by RNA polymerase II. Loca ... (more) ted in PML body; nuclear envelope; and sarcolemma. Is expressed in frontal suture frontal osteogenic front. Orthologous to human MLIP (muscular LMNA interacting protein). [provided by Alliance of Genome Resources, Jul 2025]	9	77009366	77260062	Mouse	80	name , description	gene, protein-coding, VALIDATED [RefSeq]