Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including amelogenesis; extracellular matrix disassembly; and positive regulation of antibacterial peptide production. Predicted to be located in epidermal lamellar body. Predicted to be active in
extracellular space and secretory granule. Is expressed in back skin. Orthologous to human KLK5 (kallikrein related peptidase 5). [provided by Alliance of Genome Resources, Jul 2025]
This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic clea
vage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]