jun D proto-oncogene, AP-1 transcription factor subunit
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the pro
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; cAMP response element binding activity; and protein dimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within with a negative
effect on regulation of transcription by RNA polymerase II. Acts upstream of or within chromatin remodeling and negative regulation of fat cell differentiation. Located in nucleus. Is expressed in several structures, including blood island; central nervous system; genitourinary system; musculoskeletal system; and neural retina. Orthologous to human JDP2 (Jun dimerization protein 2). [provided by Alliance of Genome Resources, Jul 2025]