Enables nuclear import signal receptor activity. Involved in NLS-bearing protein import into nucleus; cellular response to amino acid stimulus; and positive regulation of protein import into nucleus. Located in cytoplasm and nucleus. Is expressed in cerebral cortex and gonad. Orthologous to human IP
Enables aspartic endopeptidase activity, intramembrane cleaving and molecular adaptor activity. Involved in several processes, including acrosome assembly; fusion of sperm to egg plasma membrane involved in single fertilization; and protein stabilization. Acts upstream of or within several processes
, including maintenance of protein localization in endoplasmic reticulum; protein localization involved in acrosome reaction; and sperm-egg recognition. Located in endoplasmic reticulum membrane. Orthologous to human SPPL2C (signal peptide peptidase like 2C). [provided by Alliance of Genome Resources, Apr 2025]